OpenFederal grantOpen to for-profit businessesRFA-HG-27-013

GREGoRi Innovation Projects (U01 Clinical Trial Optional)

National Institutes of HealthCloses Oct 30, 2026(17 days left)$3 – $500,000

Does this fit your business?

This is an NIH research program for teams building new experimental or computational methods to diagnose rare genetic diseases, not a general small-business grant. It fits genomics, biotech, and software groups that can run serious R&D; retail, construction, transportation, and similar businesses with no research capability should not bother. Awards run up to $500,000, with about 10 expected.

Best for
Small biotech or genomics companies building diagnostic tools, Software or data teams developing computational methods for genetic analysis, Research nonprofits and universities working on rare disease genetics, Hospitals and health systems with research arms
Not for
Retail, construction, transportation, or other businesses with no genomics or computational research capability, Organizations seeking funding for operations, services, or product commercialization rather than R&D, Applicants without the scientific staff to run an experimental or computational research project
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
80
Strong Match
Technology & SoftwareMatches your industry (tech, innovation)
80
Strong Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
53
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
51
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, Colleges and universities, State and local governments, Tribal governments and organizations, Other applicants (see eligibility)
Award range
$3 – $500,000

Questions about this grant

When is the application deadline?
October 30, 2026. The notice was posted June 18, 2026.
How much funding can an applicant receive?
Awards range from $3 to $500,000, with about 10 awards expected from a total program funding of $7,500,000. No cost sharing is required.
Who can apply for this grant?
Small businesses, other for-profits, nonprofits (with or without 501(c)(3) status), public and private universities, state, local, county, city and tribal governments, public housing authorities, independent school districts, special district governments, and foreign organizations. NIH lists the full eligibility rules in Section III of the NOFO.
Can a sole proprietor or single-member LLC apply?
The facts do not say. The eligibility codes list small businesses and for-profit organizations generally, but the NOFO's Section III is the only place that would confirm whether a sole proprietor or single-member LLC qualifies.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without it may apply, as long as they are not institutions of higher education.

Summary

NIH GREGoRi innovation awards fund development and testing of highly innovative experimental or computational approaches to diagnose rare genetic diseases. Eligible applicants include small businesses, other for-profits, nonprofits, universities, state/local/tribal governments, and foreign organizations; clinical trials optional. Up to $500,000 per award.

About this grant

The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity is intended to stimulate the development and testing of highly innovative experimental or computational approaches for rare disease diagnosis, that have the potential to make transformative improvements to the current state of the art.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology

Program contact

National Institutes of Healthnhgri-gregor@mail.nih.gov301-402-2541

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