OpenFederal grantOpen to for-profit businessesPAR-24-304

Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed)

National Institutes of HealthCloses Oct 14, 2026(1 day left)

Does this fit your business?

This is an NIH/NCI program for teams that already have a cancer biomarker assay developed through NIH-supported research and need funding to adapt it and clinically validate it for real-world use in cancer detection, diagnosis, prognosis, monitoring, or treatment response prediction. It is not for early-stage technology development or clinical trials, so if your assay is still being invented or you need to run a trial, do not apply. Small businesses and for-profits can apply, but only if they're

Best for
Universities and cancer research centers with an existing NIH/NCI-funded biomarker assay ready for clinical validation, Small biotech or for-profit companies adapting and validating a cancer biomarker assay, Hospitals, clinical labs, and nonprofits with clinician and statistician partners, Tribal governments and organizations doing cancer biomarker research
Not for
Companies still building early-stage assay technology, Teams planning to run clinical trials, Businesses outside cancer diagnostics and biotech with no existing biomarker assay to validate
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
72
Good Match
Technology & SoftwareMatches your industry (technology, tech)
66
Good Match
Arts & CultureMatches your industry (arts)
59
Good Match
Education & TrainingLimit: Closes in 26 days
54
Possible Match
Environment & ConservationLimit: Closes in 26 days
54
Possible Match
Social Services & NonprofitLimit: Closes in 26 days
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Closes in 26 days
53
Possible Match
ManufacturingLimit: Closes in 26 days
51
Possible Match
Housing & Real EstateLimit: Closes in 26 days
50
Possible Match
Agriculture & FarmingLimit: Closes in 26 days
49
Possible Match
Finance & BankingLimit: Closes in 26 days
49
Possible Match
Food & BeverageLimit: Closes in 26 days
49
Possible Match
Retail & E-CommerceLimit: Closes in 26 days
47
Possible Match
Transportation & LogisticsLimit: Closes in 26 days
44
Possible Match
Construction & InfrastructureLimit: Closes in 26 days
42
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical validation, Specimen acquisition, Assay adaptation, Biomarker testing
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
October 14, 2026.
Who can apply for this grant?
Universities, hospitals, nonprofits, small businesses, other for-profits, state/local/tribal governments, and certain other entities such as HBCUs, Hispanic-serving institutions, and foreign organizations can apply. The program is aimed at teams adapting and clinically validating cancer biomarker assays, and applications should include clinical laboratory scientists and statistical experts.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses and for-profit organizations are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full NOFO (PAR-24-304) before assuming you are eligible.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH/NCI program funding revision applications to adapt and clinically validate molecular, cellular, or imaging biomarker assays for cancer detection, diagnosis, prognosis, monitoring, and treatment response prediction. Open to universities, hospitals, nonprofits, small businesses, for-profits, tribal entities, and other organizations; does not fund early-stage tech development or clinical trials.

About this grant

Through this Notice of Funding Opportunity (NOFO) is to accelerate the pace of translation of NCI-supported methods/assays/technologies (referred to as "assays") to the clinic. Specifically, the focus of this NOFO is on the adaption and clinical validation of molecular/cellular/imaging markers (referred to as "markers" r "biomarkers") for cancer detection, diagnosis, prognosis, monitoring, and prediction of response in treatment, as well as markers for cancer control and prevention. Research applications may support the acquisition of well-annotated specimens from NCI-supported or other clinical trials or observational cohorts/consortia for the purpose of clinical validation of the assay. Research projects proposed for this NOFO encourage multi-disciplinary interaction among scientific investigators, assay developers, clinicians, statisticians, and clinical laboratory staff. Clinical laboratory scientist(s) and statistical experts are highly encouraged to comprise integral parts of the application. This NOFO is not intended to support early-stage development of technology or the conduct of clinical trials, but rather the adaption and validation of assays to the point where they could be integrated into clinical trials as investigational assays/tools/devices.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Cancer research
  • Biomarker validation
  • Clinical translation

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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