OpenFederal grantOpen to for-profit businessesRFA-HG-27-012

GREGoRi Technology Integration Center (U01, Clinical Trials Optional)

National Institutes of HealthCloses Oct 30, 2026(17 days left)Up to $2,250,000

Does this fit your business?

This is a single NIH award to build one Technology Integration Center that sets standards, best practices, and benchmarking datasets for using new molecular methods to diagnose rare genetic diseases. It fits genomics, biotech, and diagnostic technology organizations with real research capacity; retail, construction, finance, and other businesses with no genomics or diagnostics work should not bother applying. Only about one award is expected, so competition is effectively winner-take-all.

Best for
Genomics and rare-disease research organizations, Healthcare and biotech companies working on molecular diagnostics, Universities and research institutions, Technology firms building diagnostic tools and datasets
Not for
Retail, construction, finance, and other businesses with no genomics or diagnostics work, Foreign organizations and non-U.S. components of U.S. organizations, Organizations seeking general small-business funding with no research capacity
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareMatches your industry (technology, tech, innovation)
89
Strong Match
Healthcare & BiotechMatches your industry (clinical)
84
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
53
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D, Technical assistance
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $2,250,000

Questions about this grant

When is the application deadline?
The application deadline is October 30, 2026.
How much funding can an applicant receive?
The largest award is $2,250,000, and total program funding is $3,000,000. About one award is expected.
Who can apply for this grant?
Eligible applicants include small businesses, other for-profit organizations, nonprofits, universities, state and local governments, federally recognized tribal governments, tribal organizations, public housing authorities, independent school districts, and special district governments. Foreign organizations and non-domestic components of U.S. organizations are not eligible to apply.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses and for-profit organizations other than small businesses are listed as eligible, but you should check Section III of the NOFO to confirm your business structure qualifies.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH funds one GREGoRi Technology Integration Center to develop standards, best practices, and benchmarking datasets for applying emerging molecular methods to rare genetic disease diagnosis. Eligible applicants include small businesses, other for-profits, universities, nonprofits, state/local/tribal governments, and other organizations; foreign entities are ineligible.

About this grant

The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. The purpose of this Notice of Funding Opportunity is to establish the GREGoRi Technology Integration Center, which will enable the development of standards and best practices for applying new and emerging molecular methods in rare disease diagnosis. A major deliverable of the Center will be a multidimensional dataset that can be used for the development and benchmarking of novel tools and strategies that facilitate rare disease diagnosis.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology

Program contact

National Institutes of Healthnhgri-gregor@mail.nih.gov301-402-2541

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