OpenFederal grantOpen to for-profit businessesRFA-MH-27-140

Optimizing Behavioral Sleep Interventions for Adolescents and Young Adults (R34 Clinical Trial Required)

National Institutes of HealthCloses Oct 22, 2026(9 days left)

Does this fit your business?

This is an NIH pilot research grant for teams running clinical trials of behavioral sleep interventions for adolescents and young adults with or at risk for mental health disorders. It is for research organizations, not companies selling products or services; if you cannot design and run a pilot clinical trial with outcome measures, do not bother applying. About 6 awards are expected from $1.5 million in total funding, so individual awards will be small.

Best for
Small businesses and for-profits with a behavioral sleep or adolescent mental health intervention to pilot-test, Universities and academic medical centers running behavioral clinical trials, Nonprofits and mental health research organizations, Interdisciplinary teams spanning sleep medicine, clinical trials methods, and behavioral science
Not for
Businesses with no research or clinical trial capability, Organizations looking for general operating or expansion funding, Foreign or international entities
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
82
Strong Match
Finance & BankingMatches your industry (economic)
64
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceMatches your industry (economic)
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
52
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials, Pilot studies, Intervention development
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Colleges and universities, Tribal governments and organizations, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is October 22, 2026. The notice was posted on May 27, 2026.
How much funding can an applicant receive?
Total program funding is $1,500,000 with about 6 awards expected, so awards are expected to be modest pilot-scale grants. The facts do not state a per-award ceiling, so the exact amount an individual applicant can receive is not published here.
Who can apply for this grant?
Eligible applicants include small businesses, for-profit organizations other than small businesses, nonprofits with or without 501(c)(3) status, private and public higher education institutions, state and local governments, school districts, housing authorities, and Native American tribal governments and organizations. Foreign organizations and non-U.S. components of U.S. organizations are not eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but whether a sole proprietor or single-member LLC qualifies is not published in this notice; check Section III of the NOFO.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are listed as eligible, other than institutions of higher education, which are covered under a separate category.

Summary

NIMH funds pilot clinical trials to adapt, optimize, and test behavioral sleep interventions for adolescents and young adults with or at risk for mental health disorders. Eligible applicants include small businesses, for-profit organizations, nonprofits, higher education institutions, state/local/tribal governments, school districts, and housing authorities.

About this grant

NIMH seeks applications for pilot research to adapt, optimize, and test behavioral interventions that address common sleep problems in adolescents and young adults with or at risk for a mental health disorder. This notice of funding opportunity (NOFO) supports pilot clinical trials designed to evaluate the feasibility, tolerability, acceptability, safety, and potential effectiveness of the approach in real world settings. Applications should aim to conduct a preliminary test of the intervention's impact on sleep and mental health outcomes, as well as an examination of the mechanisms that underlie the intervention's effectiveness, and to obtain preliminary data needed as a prerequisite for larger-scale effectiveness trials. In addition, interdisciplinary, collaborative teams of investigators from the fields of mental health, sleep medicine, developmental science, clinical trials research methods, behavioral economics, implementation science, data science, and human computer interaction are encouraged.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Topics and uses of funds

Topics

  • Health
  • Mental health
  • Sleep
  • Adolescent health
  • Behavioral intervention

Program contact

National Institutes of HealthNIMH.DSIR.inquiries@mail.nih.gov301-402-2541

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