ForecastedFederal grantOpen to for-profit businessesRFA-MH-27-110

Impact of Immunotherapies on CNS Outcomes in People with HIV: Potential Benefits, Challenges and Risks

National Institutes of HealthCloses Oct 22, 2026(9 days left)

Does this fit your business?

This is an NIH research grant for teams studying how HIV immunotherapies affect the brain and nervous system, not a business grant. It suits universities, nonprofits, governments, tribes, and for-profit or small-business research organizations with HIV, immunology, or neuroscience expertise. If your company does not do scientific research, do not bother applying.

Best for
Research teams studying HIV immunotherapies and the central nervous system, Universities and medical research institutions, Nonprofits with HIV or neuroscience research programs, Small biotech or for-profit research firms with relevant expertise
Not for
Businesses with no HIV or neuroscience research capability, Retail, finance, food, and other commercial ventures looking for operating capital
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health)
57
Good Match
Education & TrainingMatches your industry (stem)
52
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
49
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
45
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
44
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
43
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Arts & CultureLimit: Nothing in this notice points to arts & culture
42
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
42
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
39
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
39
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
39
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
39
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
39
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
39
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
39
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is October 22, 2026. The notice was posted March 15, 2026, giving applicants time to build collaborations.
How much funding can an applicant receive?
Total program funding is $2,000,000 with about 4 awards expected, so awards will be a fraction of that total. The facts do not publish a per-award dollar amount, and this is an R21/R33 biphasic award, so the amount depends on the phase.
Who can apply for this grant?
Universities, nonprofits, state and local governments, federally recognized tribes, tribal organizations, independent school districts, public housing authorities, and for-profit organizations including small businesses can apply. Faith-based and community-based organizations, federal agencies, and U.S. territories are also eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not publish rules for sole proprietors or single-member LLCs, so check the full notice of funding opportunity when it is released.
Can a nonprofit apply?
Yes. Nonprofits with or without 501(c)(3) status can apply, as long as they are not institutions of higher education in those categories.

Summary

NIH forecasted R21/R33 research grants to study how HIV immunotherapies affect the central nervous system in people with HIV, including benefits, risks, neurotoxicity, and viral reservoirs. Open to universities, nonprofits, governments, tribes, and for-profit organizations including small businesses.

About this grant

The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit biphasic research applications to evaluate the impact of HIV immunotherapies on central nervous system (CNS) outcomes in people with HIV and to identify mechanisms, benefits, and risks associated with their use in the CNS compartment. The primary goal is to generate evidence that informs whether HIV immunotherapies can safely and effectively target CNS HIV persistence while minimizing neurotoxicity and neuroinflammation. By addressing CNS-specific barriers such as blood brain barrier penetration, compartmentalized viral dynamics, and immune-mediated effects, this NOFO will support the development of strategies that contribute to sustained virologic remission across anatomical compartments and improve long-term neurologic and cognitive outcomes in people with HIV. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into the impact of HIV immunotherapies on the CNS and viral reservoirs are strongly encouraged to apply to this new NOFO. This NOFO will utilize the R21/R33 activity code.

Who can apply

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

Division of AIDS ResearchNIMH.DAR.inquiries@nih.govPlease contact via email.

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