OpenFederal grantOpen to for-profit businessesPAR-25-270

NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)

National Institutes of HealthCloses Nov 13, 2026(31 days left)Up to $1,050,000

Does this fit your business?

This NIH/NCCIH grant funds early-phase clinical trials of natural products like botanicals, dietary supplements, and probiotics, with up to $1.05 million over 3 years. It is for organizations with strong preliminary scientific evidence ready to run rigorous human trials, not for companies selling natural products or wanting to test market appeal. If you lack clinical trial infrastructure or a research team, do not apply.

Best for
Healthcare and biotech researchers running early-phase clinical trials of natural products, Universities and academic medical centers with preliminary evidence on botanicals, supplements, or probiotics, Small businesses and for-profits developing natural products with strong scientific premise, Nonprofits, tribal organizations, and government entities conducting clinical research
Not for
Businesses without clinical trial capability or scientific research staff, Companies selling natural products with no preliminary evidence or research premise, Foreign entities or organizations with non-U.S. components
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
78
Strong Match
Food & BeverageMatches your industry (nutrition)
67
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
50
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $1,050,000

Questions about this grant

When is the application deadline?
The application deadline is November 13, 2026.
How much funding can an applicant receive?
The largest award is $1,050,000, which is also the total program funding ceiling. The grant provides up to 3 years of support.
Who can apply for this grant?
Eligible applicants include small businesses, for-profit organizations, nonprofits (both 501(c)(3) and non-501(c)(3)), state and local governments, tribal governments and organizations, public and private institutions of higher education, school districts, public housing authorities, and special district governments. Foreign organizations and non-domestic components of U.S. organizations are not eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses and for-profit organizations other than small businesses are listed as eligible, so a single-member LLC may qualify as a small business, but the notice does not confirm this explicitly.
Can a nonprofit apply?
Yes. Both nonprofits having 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH/NCCIH R33 award funding early-phase clinical trials of natural products (botanicals, dietary supplements, probiotics, standardized nutritional regimens). Open to universities, nonprofits, governments, tribes, faith/community organizations, and for-profits including small businesses; foreign entities ineligible. Up to 3 years, ~$1.05M ceiling.

About this grant

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Under this NOFO, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. This NOFO will provide up to 3 years support for studies to replicate the impact of the natural product on target engagement when used by humans, and assess whether there is an association between the degree of the impact on target engagement and functional or clinical outcomes in a patient population. Applications are encouraged to design studies to determine how to optimize the impact of the natural product on target engagement by optimizing the delivery of the natural product through examination of different doses or formulations. In addition, applications can be designed to combine the natural product with another treatment approach that is known to engage the same target; or study the impact of the natural product in a target population that is more responsive. Clinical trials submitted under this NOFO are expected to be hypothesis based, milestone-driven, and directly related to the research priorities and mission of NCCIH. This R33 funding mechanism is intended to accelerate the translation of emerging basic science findings about natural products into early-stage clinical testing to determine whether continued clinical research is warranted. This NOFO will not support efficacy or effectiveness trials, nor will

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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