OpenFederal grantOpen to for-profit businessesPAR-25-226

Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)

National Institutes of HealthCloses Nov 19, 2026(37 days left)

Does this fit your business?

This NIH program funds clinical trials that bundle phase 1 with phase 1b/2a testing of new drugs or biologics for Alzheimer's disease and related dementias, specifically those working through non-amyloid, non-tau mechanisms. It is for organizations with a drug candidate ready for early-stage human trials and the capacity to run them. Companies outside biotech or drug development, or without a clinical-stage AD/ADRD candidate, should not apply.

Best for
Biotech and pharma companies with an Alzheimer's or related-dementia drug candidate ready for phase 1 testing, Small businesses and for-profits developing non-amyloid/non-tau small molecules or biologics, Universities, hospitals, and research nonprofits running early-stage clinical trials, Clinical-stage research organizations targeting cognitive or neuropsychiatric symptoms across the AD/ADRD disease
Not for
Companies with no clinical-stage drug or biologic candidate, Therapies targeting amyloid or tau mechanisms, Businesses outside healthcare and biotech with no research capability
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
80
Strong Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
49
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
November 19, 2026.
Who can apply for this grant?
Small businesses, for-profit companies, nonprofits (with or without 501(c)(3) status), universities, state, local, county, and tribal governments, independent school districts, public housing authorities, and special district governments can apply. Foreign (non-U.S.) entities, federal agencies, faith-based and community-based organizations, and certain minority-serving institutions such as HBCUs and Hispanic-serving institutions are also eligible.
Can a sole proprietor or single-member LLC apply?
The notice does not specifically address sole proprietors or single-member LLCs. Small businesses and for-profit organizations are eligible, so a single-member LLC structured as a small business may qualify, but you should confirm with NIH before applying.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH funds bundling of phase 1 with phase 1b/2a clinical trials to speed early-stage testing of non-amyloid/non-tau drugs or biologics for Alzheimer's disease and related dementias. Eligible applicants include small businesses, for-profits, universities, nonprofits, tribal and state/local governments; foreign entities may also apply.

About this grant

The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications that bundle independent protocols for phase 1 clinical trials with phase 1b/phase 2a clinical trials to streamline the early-stage evaluation of promising pharmacological interventions for Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD). Candidate interventions evaluated through this program, which can include small molecules or biologics for example, must engage non-amyloid/non-tau mechanisms and aim to address cognitive and/or neuropsychiatric symptoms in individuals across the spectrum from pre-symptomatic to more severe stages of disease. This NOFO uses the UG3/UH3 phased award mechanism and proposals must include prespecified, go/no-go safety and tolerability milestones that gate the advance from phase 1 to latter stages of clinical development.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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