OpenFederal grantOpen to for-profit businessesPAR-25-269

NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)

National Institutes of HealthCloses Nov 13, 2026(31 days left)Up to $350,000

Does this fit your business?

This is an NIH research grant for early-phase clinical trials of natural products like botanicals, probiotics, and dietary supplements, not a business development or product launch fund. It fits organizations that can run milestone-driven human trials with scientific rigor. Retailers, marketers, and companies without clinical research capability should not bother applying.

Best for
Universities and research institutions running early-phase clinical trials of botanicals, probiotics, or dietary-supplem
Not for
Businesses selling natural products with no clinical research capability, Organizations outside healthcare, biotech, nutrition research, or clinical trials, Foreign (non-U.S.) entities
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
76
Strong Match
Technology & SoftwareMatches your industry (innovation)
68
Good Match
Food & BeverageMatches your industry (nutrition)
64
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
52
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
48
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Colleges and universities, Tribal governments and organizations, Other applicants (see eligibility)
Award range
Up to $350,000

Questions about this grant

When is the application deadline?
November 13, 2026.
How much funding can an applicant receive?
The largest award is $350,000, and total program funding is also listed at $350,000.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), public and private institutions of higher education, state, county, city, township, and special district governments, public housing authorities, independent school districts, federally recognized and other Native American tribal governments and organizations, and certain other entities such as HBCUs, Hispanic-serving institutions, and Alaska Native and Native Hawaiian Serving Institutions. Foreign organizations are not eligible, and non-domestic components of U.S. organizations cannot apply.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify as small businesses for this program.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH funds investigator-initiated early-phase clinical trials of natural products (botanicals, probiotics, dietary supplements) with strong scientific premise. Up to 3 years R61 milestone-driven testing of pharmacokinetics/bioavailability/mechanism, then up to 3 more years R33 to replicate target engagement and link to clinical outcomes. Open to universities, nonprofits, businesses, governments, US

About this grant

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, probiotics, and products marketed as dietary supplements), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Under this NOFO, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. This NOFO will provide up to three years (R61 phase) of support for milestone-driven testing of pharmacokinetics, bioavailability, and assessment of the natural products effect (i.e., measure of mechanism of action) when used by humans on a specified target measure. If milestones in the R61 phase are achieved, up to 3 years of additional support (R33 phase) may be awarded to replicate the impact of the natural product on target engagement(s) when used by humans and assess whether there is an association between the degree of the impact on the target engagement and clinical outcomes in a participant population. Applications are encouraged to design R33 studies to determine how to optimize the impact of the natural product on the target engagement by optimizing the delivery of the natural product through examination of different doses or formulations. In addition, applications can be designed to combine the natural product with another treatment approach that is known to impact the same target engagement measure; or study the impact of the natural product in a population that is more responsive,

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Topics and uses of funds

Topics

  • Health
  • Science
  • Clinical research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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