OpenFederal grantRFA-AT-25-003

HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

National Institutes of HealthCloses Nov 23, 2026(41 days left)Up to $375,000

Does this fit your business?

This is an NIH research grant for U.S. colleges and universities, not for businesses. It funds basic and mechanistic pain research led by R15-eligible principal investigators and involves undergraduate, graduate, or health-professional trainees. If you run a for-profit business of any kind, including a small business or sole proprietorship, do not apply; nonprofits are also not eligible.

Best for
R15-eligible U.S. colleges and universities, Academic principal investigators running basic or mechanistic pain research, Institutions engaging undergraduate, graduate, or health-professional trainees in research
Not for
For-profit businesses, including small businesses and sole proprietors, Nonprofit organizations, Foreign or non-U.S. entities
Estimated fit by industry, best first
IndustryEstimated fit
Agriculture & FarmingLimit: Only governments, nonprofits, tribes or universities may apply —…
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Worth Exploring
Arts & CultureLimit: This program does not accept nonprofit applicants.
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Construction & InfrastructureLimit: Only governments, nonprofits, tribes or universities may apply —…
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Worth Exploring
Education & TrainingLimit: This program does not accept nonprofit applicants.
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Worth Exploring
Energy & Clean TechLimit: Only governments, nonprofits, tribes or universities may apply —…
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Worth Exploring
Environment & ConservationLimit: This program does not accept nonprofit applicants.
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Worth Exploring
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Finance & BankingLimit: Only governments, nonprofits, tribes or universities may apply —…
0
Worth Exploring
Food & BeverageLimit: Only governments, nonprofits, tribes or universities may apply —…
0
Worth Exploring
Healthcare & BiotechLimit: Only governments, nonprofits, tribes or universities may apply —…
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Worth Exploring
Housing & Real EstateLimit: Only governments, nonprofits, tribes or universities may apply —…
0
Worth Exploring
ManufacturingLimit: Only governments, nonprofits, tribes or universities may apply —…
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Worth Exploring
Retail & E-CommerceLimit: Only governments, nonprofits, tribes or universities may apply —…
0
Worth Exploring
Social Services & NonprofitLimit: This program does not accept nonprofit applicants.
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Worth Exploring
Technology & SoftwareLimit: Only governments, nonprofits, tribes or universities may apply —…
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Worth Exploring
Transportation & LogisticsLimit: Only governments, nonprofits, tribes or universities may apply —…
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Worth Exploring

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Colleges and universities, Other applicants (see eligibility)
Award range
Up to $375,000

Questions about this grant

When is the application deadline?
The application deadline is November 23, 2026.
How much funding can an applicant receive?
The largest award is $375,000. No other award amounts are published.
Who can apply for this grant?
U.S. institutions of higher education, both public and private, plus certain other categories such as HBCUs, Hispanic-serving institutions, tribal colleges, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander serving institutions. Foreign organizations are not eligible. Businesses and nonprofits are not eligible.
Can a sole proprietor or single-member LLC apply?
No. For-profit businesses, including small businesses, may not apply. Only U.S. institutions of higher education and similar academic entities are eligible.
Can a nonprofit apply?
No. The program does not accept nonprofit applicants. Eligible applicants are U.S. institutions of higher education and the specific academic categories listed in the eligibility text.

Summary

NIH R15 grant for eligible academic institutions to fund basic and mechanistic pain research by R15-eligible PIs, build interdisciplinary research partnerships, and engage undergraduate, graduate, and health-professional trainees in pain research projects. Applicants must be U.S. institutions of higher education; businesses and nonprofits are not eligible.

About this grant

The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.

Who can apply

Our reading of the listing: for-profit businesses are not eligible for this one.

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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