OpenFederal grantOpen to for-profit businessesPAR-25-255

Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)

National Institutes of HealthCloses Nov 5, 2026(23 days left)

Does this fit your business?

This is an NIH research grant (R01) for developing new theory and methods to understand how genetic and non-genetic factors shape complex human traits. It is for serious research teams — universities, nonprofits, and businesses with genetics, biostatistics, or computational modeling capability — not for companies looking for general operating money. Retail, finance, housing, and other businesses with no research mission should not bother applying.

Best for
Research universities and academic labs, Biotech and genomics-focused small businesses, Nonprofits and research institutes running genetics or population-science research, Interdisciplinary teams combining biology, social science, and data modeling
Not for
Retail, e-commerce, finance, housing, or other businesses with no research focus, Organizations seeking funding for operations, equipment, or services rather than research, Applicants without access to large-scale datasets or quantitative modeling capability
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
79
Strong Match
Social Services & NonprofitMatches your industry (social)
70
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is November 5, 2026.
Who can apply for this grant?
Eligible applicants include small businesses, for-profit organizations, nonprofits, colleges and universities, state, local, and tribal governments, public housing authorities, independent school districts, and certain foreign entities such as non-U.S. organizations. Faith-based and community-based organizations, HBCUs, Hispanic-serving institutions, and Alaska Native and Native Hawaiian serving institutions are also listed as eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full notice or contact NIH before applying.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH R01 grant for novel theory and methods development to understand how genetic and non-genetic factors contribute to complex trait variation. Eligible applicants include small businesses, for-profit organizations, nonprofits, universities, state/local/tribal governments, and foreign entities. Funds interdisciplinary research using theory, modeling, and large-scale datasets.

About this grant

The goal of this NOFO is to support applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary drawing from the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, modeling, and validation with available large-scale datasets.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Science
  • Health
  • Genetics
  • Research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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