OpenFederal grantOpen to for-profit businessesRFA-MH-27-125

Mechanistic Evaluation of Therapeutic Targets derived from Treatable Traits to Improve CNS Outcomes in People with HIV (R21/R33 Clinical Trial Not Allowed)

National Institutes of HealthCloses Oct 28, 2027(380 days left)

Does this fit your business?

This is an NIH research grant for scientists studying how HIV damages the central nervous system, with a phased R21/R33 structure and no clinical trials allowed. It fits labs and research-driven biotech teams; a typical small business outside health research should not bother. The award amount is not published, and foreign organizations cannot apply.

Best for
Research teams studying HIV and the central nervous system, Universities and academic medical centers, Biotech or life-science companies doing early-stage research, Nonprofits with scientific research programs
Not for
Businesses outside health and biotech research, Anyone wanting to run a clinical trial, Organizations without research capability
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
77
Strong Match
Education & TrainingMatches your industry (stem)
69
Good Match
Arts & CultureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
53
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
53
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
53
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
52
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
October 28, 2027. The notice was posted September 30, 2026, so the window is long.
Who can apply for this grant?
A long list: small businesses, other for-profit companies, nonprofits with and without 501(c)(3) status, public and private colleges and universities, state, county, city, township and special district governments, federally recognized tribes, other tribal organizations, public housing authorities, independent school districts, and other organizations named in the NOFO. Foreign organizations, foreign components of U.S. organizations, and non-U.S. parts of U.S. organizations cannot apply. The NOFO's Section III has the full eligibility details.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not spell out rules for sole proprietors or single-member LLCs, so check Section III of the NOFO before counting on it.
Can a nonprofit apply?
Yes. Both 501(c)(3) nonprofits and nonprofits without 501(c)(3) status can apply, as long as they are U.S.-based.

Summary

NIH R21/R33 phased research grants to identify modifiable mechanisms and therapeutic targets for CNS complications of HIV, using patient phenotyping and in-vitro/in-vivo model validation. Eligible applicants include small businesses, for-profits, nonprofits, universities, state/local/tribal governments and other organizations; clinical trials not allowed.

About this grant

The purpose of this notice of funding opportunity (NOFO) is to identify modifiable mechanisms and therapeutic targets to address central nervous system (CNS) complications associated with human immunodeficiency virus (HIV). The initiative supports a phased research approach beginning with the identification of patient phenotypes characterized by convergent pathophysiological features, followed by the discovery and experimental validation of molecular mechanisms using innovative in-vitro and in-vivo models. The goal of this NOFO is to advance therapeutic target, and intervention discovery to address the multifactorial and heterogeneous nature of HIV-associated CNS dysfunction.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of HealthNIMH.DAR.inquiries@nih.gov301-402-2541

Related grants

Open opportunities funding similar work, from the same funder or in the same place.

All grantsGrants by stateGrants by industry