Immune Tolerance Network (UM1 Clinical Trial Required)

Does this fit your business?

This is an NIH/NIAID cooperative agreement to run clinical trials and mechanistic research on immune tolerance in transplantation, autoimmune disease, and asthma/allergies, with about one award expected from roughly $22 million in total program funding. It is for research organizations capable of conducting human clinical trials, not for businesses seeking general operating or commercialization money. If your organization does not do biomedical research or clinical trials, do not bother applying

Best for

Healthcare and biotech research organizations, Universities and academic medical centers, Nonprofits and for-profits running clinical trials, Small businesses with immune-tolerance research programs

Not for

Construction, finance, manufacturing, or energy companies, Businesses seeking funding unrelated to clinical research, Organizations unable to conduct human clinical trials

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for

Research, R&D, Operating support

Who can apply

Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?

The application deadline is January 29, 2027. The opportunity was posted on June 24, 2026.

How much funding can an applicant receive?

Total program funding is $21,986,000, with about one award expected. The facts do not state a per-award ceiling, so the exact amount an individual recipient can receive is not published.

Who can apply for this grant?

Eligible applicants include small businesses, for-profit organizations other than small businesses, nonprofits with and without 501(c)(3) status, public and private institutions of higher education, state, county, city, and special district governments, federally recognized and other Native American tribal governments and organizations, public housing authorities, independent school districts, and other organizations listed in the eligibility text, including foreign institutions and faith-based or community-based organizations.

Can a sole proprietor or single-member LLC apply?

The facts do not specifically address sole proprietors or single-member LLCs. Small businesses and for-profit organizations generally are listed as eligible, but you should confirm your entity type qualifies under the full eligibility text.

Can a nonprofit apply?

Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH funding to continue the Immune Tolerance Network, a consortium that designs and conducts clinical trials and mechanistic studies of tolerogenic therapies for allergic diseases, autoimmune diseases, and transplant-related immune disorders. Eligible applicants include small businesses, for-profits, nonprofits, universities, governments, tribal entities, and foreign institutions.

About this grant

Who can apply

Topics and uses of funds

Program contact