NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)

Does this fit your business?

This is an NIH research grant for prospective observational studies or biomarker validation studies that require collecting new data or biospecimens or continuing to analyze existing ones. It fits research-capable organizations — universities, hospitals, nonprofits, and small businesses with genuine research operations — not companies looking for general business funding. If your business does not conduct health or biomedical research, this is not worth your time.

Best for

Research teams at universities and hospitals running prospective observational or biomarker validation studies, Small businesses and for-profit companies with oral health or biomedical research capabilities, Nonprofits with 501(c)(3) status conducting health research, State, local, and tribal governments with research programs

Not for

Retail, finance, housing, and other businesses with no research component, Foreign organizations or U.S. organizations with foreign components, Organizations seeking funding for anything other than research

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for

Research

Who can apply

Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Award range

Up to $500,000

Questions about this grant

When is the application deadline?

The application deadline is July 5, 2029.

How much funding can an applicant receive?

The largest award is $500,000. No other award amounts are published in the notice.

Who can apply for this grant?

Eligible applicants include small businesses, for-profit organizations other than small businesses, nonprofits (both with and without 501(c)(3) status), public and private institutions of higher education, state, county, city, and township governments, special district governments, public and Indian housing authorities, independent school districts, and federally recognized and other Native American tribal organizations. Foreign organizations, non-U.S. components of U.S. organizations, and foreign components are not eligible. The NOFO's Section III has additional eligibility details.

Can a sole proprietor or single-member LLC apply?

The notice lists small businesses among eligible applicant types, but it does not specifically address sole proprietors or single-member LLCs. Check Section III of the NOFO or confirm with NIH before assuming you qualify.

Can a nonprofit apply?

Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH cooperative agreement (U01) funding investigator-initiated prospective observational studies or biomarker validation studies requiring prospective collection or continued analysis of data/biospecimens. Eligible applicants include small businesses, for-profit organizations, nonprofits, universities, and state, local, and tribal governments; foreign entities are not eligible.

About this grant

Who can apply

Topics and uses of funds

Program contact