OpenFederal grantOpen to for-profit businessesRFA-OD-27-005

INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)

National Institutes of HealthCloses Jun 15, 2028(611 days left)

Does this fit your business?

This is an NIH research program for organizations that can design and run milestone-driven clinical trials treating critical and co-occurring health conditions in people with Down syndrome. It is a phased R61/R33 award: up to two years of planning and preliminary work, then possible transition to up to three years of clinical trial support, capped at five years total. Retail, finance, housing, and any business without clinical research capability should not bother applying.

Best for
Biotech and healthcare companies developing clinical trials for Down syndrome-related conditions, Universities and academic medical centers running milestone-driven clinical research, Nonprofits with clinical trial research programs, Research teams with preliminary data ready for phased R61/R33 development
Not for
Retail, e-commerce, finance, or housing businesses with no clinical research angle, Organizations without the capacity to run clinical trials or meet measurable R61 milestones, Applicants seeking general operating funding or non-research projects
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
87
Strong Match
Technology & SoftwareMatches your industry (innovation)
74
Good Match
Transportation & LogisticsMatches your industry (transit)
66
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials, Planning
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
June 15, 2028.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), universities, state/local/tribal governments, public housing authorities, independent school districts, and other entities may apply. Foreign organizations and foreign components of U.S. organizations are also eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check Section III of the NOFO.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH INCLUDE Project phased R61/R33 awards to develop milestone-driven clinical trials treating critical and co-occurring health conditions in individuals with Down syndrome. Eligible applicants include small businesses, for-profit organizations, nonprofits, universities, state/local/tribal governments, and other entities; foreign organizations may apply.

About this grant

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) encourages Exploratory/Developmental Phased Innovation (R61/R33) grant applications to support development of clinical trials to treat critical and co-occurring health conditions in individuals with Down syndrome. The proposed research aims should be milestone-driven. The total project period for an application submitted in response to this NOFO may not exceed five years. This NOFO provides support for up to two years (R61 phase) for preliminary/developmental/planning studies, followed by possible transition to clinical trial support (R33) of up to three years, although the total duration of the award may not exceed five years. This NOFO requires measurable R61 milestones.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of HealthDownSyndromeINCLUDE@mail.nih.gov301-402-2541

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