OpenFederal grantOpen to for-profit businessesRFA-OD-27-004

INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

National Institutes of HealthCloses Jun 15, 2028(611 days left)Up to $500,000

Does this fit your business?

This is an NIH research grant for groundbreaking, highly innovative research on Down syndrome and its co-occurring conditions — not a business grant. If you are a small business or lab that can run a serious biomedical research project, it may fit; if you run a retail, finance, housing, or general services business with no research capacity, do not bother. No preliminary data are required, but projects must show potential for major impact.

Best for
Research teams pursuing groundbreaking or unconventional Down syndrome research, Small businesses and for-profits developing transformative health or biotech technologies, Nonprofits with 501(c)(3) status running research programs, Universities and higher education institutions
Not for
Businesses with no research component, such as retail, finance, or housing operations, Organizations seeking funding for services, training, or operations rather than research, Applicants needing guaranteed funding — only about 4 awards are expected
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
87
Strong Match
Technology & SoftwareMatches your industry (tech)
75
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $500,000

Questions about this grant

When is the application deadline?
June 15, 2028.
How much funding can an applicant receive?
The largest single award is $500,000, from a total program funding pool of $3,000,000. About 4 awards are expected.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), higher education institutions, state, county, city, township, and special district governments, federally recognized Native American tribal governments and tribal organizations, independent school districts, public and Indian housing authorities, and others as defined in the NOFO. Foreign organizations and foreign components of U.S. organizations are also eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify; check Section III of the NOFO.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible.

Summary

NIH INCLUDE Project Transformative Research Awards fund groundbreaking, highly innovative research on Down syndrome and its co-occurring conditions. Eligible applicants include small businesses, for-profits, nonprofits, higher education institutions, state/local/tribal governments, and others; foreign entities may also apply. No preliminary data required.

About this grant

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of HealthDownSyndromeINCLUDE@mail.nih.gov301-402-2541

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