OpenFederal grantOpen to for-profit businessesRFA-DK-27-108

Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)

National Institutes of HealthCloses Mar 10, 2027(148 days left)Up to $500,000

Does this fit your business?

This is an NIH research grant to continue the CaRe-T1D consortium, which studies cardiovascular disease in people with type 1 diabetes. It is for research organizations — universities, nonprofits, and research-oriented businesses — that can contribute to a collaborative biomedical research effort, not for companies looking for general business funding. If you are not running or partnering on type 1 diabetes or cardiovascular research, do not bother applying.

Best for
Research universities and academic medical centers, Nonprofits with biomedical research programs, Small biotech or research firms with type 1 diabetes expertise, Tribal, state, or local government entities running health research
Not for
Businesses outside biomedical research, such as retail, construction, or logistics firms, Organizations without type 1 diabetes or cardiovascular research capability, Foreign entities or organizations with non-domestic components
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
72
Good Match
Arts & CultureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
Social Services & NonprofitLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
53
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
53
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
53
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
51
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
51
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $500,000

Questions about this grant

When is the application deadline?
The application deadline is March 10, 2027.
How much funding can an applicant receive?
The largest single award is $500,000. The total program funding is $6,000,000, with about 8 awards expected.
Who can apply for this grant?
Eligible applicants include state, county, city, township, and special district governments, federally recognized and other Native American tribal organizations, public housing authorities, independent school districts, nonprofits with and without 501(c)(3) status, private and public institutions of higher education, for-profit organizations other than small businesses, and small businesses. Foreign organizations and non-domestic components of U.S. organizations are not eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. The eligibility list names small businesses and for-profit organizations generally, but it does not specifically address sole proprietors or single-member LLCs, so check Section III of the NOFO before assuming you qualify.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible.

Summary

NIH U01 cooperative agreement to continue the CaRe-T1D consortium, supporting collaborative research on cardiovascular disease mechanisms in type 1 diabetes. Eligible applicants include states, local governments, tribes, nonprofits, higher education institutions, and for-profit organizations including small businesses; foreign entities are not eligible.

About this grant

The NIH Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) was created to improve research on type 1 diabetes (T1D) and cardiovascular disease (CVD). Cardiovascular complications remain the top cause of death among people with T1D and greatly shorten lifespan. The mechanisms underlying atherosclerosis, cardiomyopathy, endothelial dysfunction, and cardiac autonomic neuropathy in T1D remain poorly understood. While managing traditional risk factors—such as high blood glucose, high blood pressure, and elevated cholesterol lower cardiovascular risk, a significant residual risk remains even with optimal control. In addition to atherosclerosis, both diastolic and systolic diabetic cardiomyopathy play a major role in morbidity and mortality among these patients. Currently, no therapies are specifically approved to prevent or treat these common and severe cardiovascular issues in T1D. The purpose of this NOFO is to promote collaborative and interdisciplinary research aimed at enhancing the understanding of the development of CVD in individuals with T1D and the differences with CVD in T1D by continuing the efforts of the CaRe-T1D consortium.This NOFO is associated with the Special Diabetes Program (https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of HealthNIDDK_DEM@nih.gov301-402-2541

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