Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products - Preliminary Product/Lead Series Identification and Combination Product Prototype (R33 - Clinical Trial Not Allowed)

Does this fit your business?

This is an NIH research grant for moving early lab discoveries on heart, lung, blood, and sleep disease treatments toward candidates ready for human testing, covering small molecules, biologics, and combination products. It fits small biotech and life-science businesses, universities, and nonprofits doing that specific translational work. If you are not developing a therapeutic or combination product for HLBS diseases, do not apply.

Best for

Small biotech or life-science businesses developing small molecules, biologics, or combination products for heart, lung,, blood, or sleep diseases, Universities and academic translational research groups moving basic discoveries toward human testing, Nonprofits and research institutes with early-stage therapeutic candidates, Teams preparing to enter the NHLBI Catalyze Preclinical Program

Not for

Retail, e-commerce, finance, housing, and other businesses outside healthcare, biotech, or translational science, Projects already past product definition, such as those ready for preclinical development or human trials, Foreign organizations, which are not eligible to apply

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for

Research, R&D

Who can apply

Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?

The application deadline is 2027-12-23.

Who can apply for this grant?

Eligible applicants include small businesses, for-profit organizations other than small businesses, nonprofits (with or without 501(c)(3) status), public and private institutions of higher education, state, county, city, and township governments, special district governments, independent school districts, public housing authorities, and federally recognized and other Native American tribal governments and organizations. The eligibility text also lists Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, HBCUs, tribally controlled colleges, faith-based and community-based organizations, and federal agencies. Foreign organizations are not eligible to apply, U.

Can a sole proprietor or single-member LLC apply?

The facts do not say. The eligibility codes list small businesses and for-profit organizations generally, but there is no specific statement about sole proprietors or single-member LLCs, so it is not published here.

Can a nonprofit apply?

Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH NHLBI Catalyze program funds early-stage translational research to identify and characterize therapeutic candidates (small molecules, biologics, combination products) for heart, lung, blood, and sleep diseases. Eligible applicants include small businesses, for-profit organizations, universities, nonprofits, and state/local/tribal governments.

About this grant

Who can apply

Topics and uses of funds

Program contact