OpenFederal grantOpen to for-profit businessesRFA-DC-27-004

BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)

National Institutes of HealthCloses Feb 11, 2027(121 days left)Up to $700,000

Does this fit your business?

This is an NIH BRAIN Initiative exploratory research grant (R61) for multidisciplinary teams running invasive neural recording and stimulation studies in the human brain, with clinical trials not allowed. It suits research universities, neurotech small businesses, and nonprofits with the clinical access and scientific depth to run human intracranial studies. Retail, construction, logistics, and other businesses with no neuroscience research role should not bother applying.

Best for
Multidisciplinary research teams at universities with access to invasive neurosurgery patients, Neurotech small businesses developing invasive recording or stimulation devices, Nonprofits and research institutes running human brain research programs, NIH-eligible US organizations joining the BRAIN Initiative consortium
Not for
Retail, construction, or logistics businesses with no neuroscience research role, Organizations planning clinical trials (this NOFO does not allow them), Foreign entities or US organizations with foreign components
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
80
Strong Match
Technology & SoftwareMatches your industry (tech)
76
Strong Match
Social Services & NonprofitMatches your industry (community, social)
74
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
53
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
51
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Planning, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $700,000

Questions about this grant

When is the application deadline?
The application deadline is February 11, 2027.
How much funding can an applicant receive?
The largest award is $700,000, with total program funding of $6,000,000 and about 5 awards expected.
Who can apply for this grant?
Eligible applicants include universities, nonprofits, governments, tribes, and for-profit organizations including small businesses. Foreign entities are not eligible to apply.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses are listed as eligible, but you should check Section III of the NOFO to confirm your business structure qualifies.
Can a nonprofit apply?
Yes, nonprofits with or without 501(c)(3) status may apply.

Summary

NIH BRAIN Initiative exploratory research grants (R61, clinical trial not allowed) for multidisciplinary teams conducting invasive neural recording and stimulation studies in the human brain. Eligible applicants include universities, nonprofits, governments, tribes, and for-profit organizations including small businesses; foreign entities are not eligible.

About this grant

Invasive surgical procedures in humans offer the unique opportunity to intracranially record and stimulate neuronal activity within precisely localized brain structures, enabling high-impact human neuroscience investigations. This NOFO seeks exploratory research projects, from newly formed or established multi-disciplinary teams, to understand how dynamic activity of single cells and ensembles of neurons in spatially organized networks gives rise to the internal states we experience as sensations, perceptions, emotions, thoughts, and memories, and to observable motor and social behaviors. The research should be proposed as exploratory research and planning activities to establish feasibility and early-stage development that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent research project grant applications using invasive neural recording and stimulation technologies in the human brain. Projects should maximize opportunities to conduct innovative in vivo human neuroscience research made available by direct access to the brain from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and by quantitative, mechanistic models where appropriate. Recipients will join a consortium working group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Science
  • Health
  • Technology

Program contact

National Institutes of HealthBRAINeROH@ninds.nih.gov301-402-2541

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