OpenFederal grantOpen to for-profit businessesPAR-27-081

Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

National Institutes of HealthCloses Mar 5, 2027(143 days left)

Does this fit your business?

This is an NIH research grant (R01) for teams that already hold validated hit compounds and bioassays and want to develop small-molecule chemical probes for brain-related targets tied to NIMH, NIDA, NEI, or NIA missions. If you are not running a medicinal chemistry or neuroscience drug-discovery program, do not apply; no amount of general business merit substitutes for compounds in hand. The award amount is not published.

Best for
Research labs with validated hit compounds and bioassays for brain targets, Universities and medical research institutions, Biotech and pharmaceutical small businesses, Nonprofits doing neuroscience or drug-discovery research
Not for
Businesses without an active neuroscience drug-discovery program, Organizations without validated hit compounds and bioassays in hand, Retail, finance, or housing ventures looking for general business funding
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
87
Strong Match
Technology & SoftwareCurrently accepting applications
70
Good Match
Education & TrainingMatches your industry (stem)
69
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
March 5, 2027.
Who can apply for this grant?
Universities (public, state-controlled, and private), nonprofits with and without 501(c)(3) status, small businesses and other for-profit companies, state/local/tribal governments, school districts, public housing authorities, and other organizations named in the NOFO. Foreign organizations and foreign components of U.S. organizations are also eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses and for-profit organizations generally are listed as eligible, but the NOFO's Section III eligibility information is the authority on specific business structures.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible.

Summary

NIH research grants (R01) to discover and develop small-molecule chemical probes for novel brain targets relevant to NIMH, NIDA, NEI, and NIA missions. Applicants must have validated hit compounds and bioassays. Eligible applicants include universities, nonprofits, businesses (small and other for-profits), governments, and tribal entities; foreign organizations may also apply.

About this grant

The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Science
  • Health
  • Technology

Program contact

National Institutes of HealthNIA-NOFO-Scientific@nih.gov301-402-2541

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