OpenFederal grantOpen to for-profit businessesPA-25-301

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

National Institutes of HealthCloses Jan 7, 2028(451 days left)

Does this fit your business?

This is NIH's R01 grant for a single, well-defined health-related research project that fits the mission of one or more participating NIH Institutes and Centers, with clinical trials explicitly not allowed. It is for organizations that can run serious biomedical or health research, especially in healthcare and biotech. Retail, finance, housing, and other businesses with no research component should not bother applying.

Best for
Healthcare and biotech organizations running health-related research projects, Universities and other higher education institutions with research programs, Nonprofits with a 501(c)(3) status or without it, focused on health research, Small businesses and for-profit companies doing health research
Not for
Retail, e-commerce, finance, housing, and other businesses with no health research component, Organizations looking to run clinical trials, Applicants seeking general business funding rather than research funding
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
83
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is January 7, 2028.
Who can apply for this grant?
Eligible applicants include small businesses, for-profit organizations other than small businesses, nonprofits (both with and without 501(c)(3) status), state, county, city and tribal governments, public housing authorities, independent school districts, and public, private, and state-controlled institutions of higher education. Other eligible applicants include foreign organizations, HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Can a sole proprietor or single-member LLC apply?
The facts do not say. The notice lists small businesses and for-profit organizations as eligible, but it does not specify whether sole proprietors or single-member LLCs qualify.
Can a nonprofit apply?
Yes. Nonprofits that have a 501(c)(3) status with the IRS, and nonprofits that do not have a 501(c)(3) status (other than institutions of higher education), are both listed as eligible applicants.

Summary

NIH R01 grants fund discrete health-related research projects aligned with the missions of participating NIH Institutes and Centers. Eligible applicants include small businesses, for-profit organizations, nonprofits, universities, state/local/tribal governments, and others; clinical trials are not allowed.

About this grant

The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.This Notice of Funding Opportunity does not accept applications proposing clinical trial(s).

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

Related grants

Open opportunities funding similar work, from the same funder or in the same place.

All grantsGrants by stateGrants by industry