OpenFederal grantOpen to for-profit businessesPAR-27-098

SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)

National Institutes of HealthCloses Apr 5, 2029(905 days left)

Does this fit your business?

This NIH pilot funds late-stage commercialization work — clinical studies, IND/IDE-enabling studies, manufacturing scale-up, regulatory support — for U.S. small businesses that already hold an NIH SBIR or STTR Phase II award. If you do not have a prior NIH SBIR/STTR Phase II award, do not bother applying; you are ineligible. Nonprofits, foreign entities, and anyone without that Phase II track record should look elsewhere.

Best for
U.S. small businesses with prior NIH SBIR/STTR Phase II awards, Biotech and medtech companies preparing IND/IDE submissions or clinical studies, SBIR/STTR grantees needing manufacturing scale-up or regulatory support
Not for
First-time applicants without an NIH SBIR/STTR Phase II award, Nonprofits and organizations that are not small businesses, Foreign or non-U.S. entities
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareMatches your industry (tech, sbir, sttr)
100
Strong Match
Healthcare & BiotechMatches your industry (clinical)
97
Strong Match
Finance & BankingMatches your industry (business)
88
Strong Match
ManufacturingMatches your industry (manufacturing)
88
Strong Match
Retail & E-CommerceMatches your industry (small business)
86
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match
Arts & CultureLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Education & TrainingLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Environment & ConservationLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Social Services & NonprofitLimit: This program does not accept nonprofit applicants.
0
Worth Exploring

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Technical assistance
Who can apply
Small businesses

Questions about this grant

When is the application deadline?
April 5, 2029.
Who can apply for this grant?
Only U.S. small business concerns, as defined by the SBA, that hold a prior NIH SBIR/STTR Phase II award. Foreign organizations and non-U.S. components of U.S. organizations are not eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Eligibility is limited to U.S. small business concerns as defined by the SBA, so check the SBA size standards and the NOFO's Section III to confirm your entity qualifies.
Can a nonprofit apply?
No. Only U.S. small business concerns may apply; nonprofits are not eligible for this program.

Summary

NIH SBIR/STTR Commercialization Readiness Pilot: only U.S. small business concerns with prior NIH SBIR/STTR Phase II awards may apply. Funds late-stage R&D and technical assistance to move projects toward commercialization, including clinical studies, IND/IDE-enabling work, manufacturing scale-up, and regulatory support.

About this grant

The Commercialization Readiness Pilot (CRP) program helps small business concerns (SBCs) move NIH-funded SBIR or STTR projects from late-stage development to commercialization. The CRP supports later-stage research and development (R&D) and/or technical assistance that Phase II and Phase IIB Strategic Breakthrough awards do not typically support. This includes:Independent replication or confirmation of key studiesIND- or IDE-enabling studiesClinical studiesManufacturing scale-up and related quality activitiesRegulatory and other specialized technical supportSBCs may subcontract (outsource) a significant amount of the work in a CRP to meet the project goals.

Who can apply

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity.Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.

Topics and uses of funds

Topics

  • Health
  • Technology
  • Science

Program contact

National Institutes of HealthSEEDinfo@nih.gov301-402-2541

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