OpenFederal grantOpen to for-profit businessesPA-27-101

NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)

National Institutes of HealthCloses Apr 5, 2029(905 days left)

Does this fit your business?

This is a follow-on NIH award for US small businesses that already finished or are finishing an NIH SBIR or STTR Phase II project and need money for later-stage R&D before commercialization. If your company has never held an NIH Phase II award, do not bother applying; you are ineligible. Nonprofits, foreign entities, and projects seeking a second Phase IIB award are also out.

Best for
US small businesses with a prior NIH SBIR or STTR Phase II award, Technology and software companies doing later-stage health R&D, Healthcare and biotech companies commercializing an NIH-funded project
Not for
First-time applicants with no prior NIH SBIR or STTR Phase II award, Nonprofits and organizations without a for-profit small business structure, Companies with foreign ownership components or international funded collaborations
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareMatches your industry (technology, tech, innovation, sbir, sttr)
100
Strong Match
Healthcare & BiotechMatches your industry (clinical)
99
Strong Match
Finance & BankingMatches your industry (business)
86
Strong Match
Retail & E-CommerceMatches your industry (small business)
85
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match
Arts & CultureLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Education & TrainingLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Environment & ConservationLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Social Services & NonprofitLimit: This program does not accept nonprofit applicants.
0
Worth Exploring

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research
Who can apply
Small businesses

Questions about this grant

When is the application deadline?
The application deadline is April 5, 2029. Applications are accepted on multiple due dates, and renewal/resubmission applications must be submitted within the first six due dates after the Phase II budget period expires.
Who can apply for this grant?
Only United States small business concerns that have previously received an NIH SBIR or STTR Phase II award can apply. Foreign organizations and non-U.S. components of U.S. organizations are not eligible, and only one Phase IIB Strategic Breakthrough award is allowed per project.
Can a sole proprietor or single-member LLC apply?
The facts say only that eligible applicants are US small business concerns with a prior NIH SBIR or STTR Phase II award. They do not specify whether sole proprietors or single-member LLCs qualify, so check the NOFO's eligibility section.
Can a nonprofit apply?
No. This program accepts only small business applicants, so nonprofits are not eligible.

Summary

NIH SBIR Phase IIB Strategic Breakthrough award for US small businesses that previously received an NIH SBIR or STTR Phase II award. Funds later-stage R&D to bridge the gap between Phase II and commercialization. Cost sharing required; one award per project.

About this grant

The NIH Phase IIB Strategic Breakthrough award bridges the funding gap between the end of a Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II award and commercialization. The Phase IIB Strategic Breakthrough provides previously funded NIH SBIR or STTR projects additional support for later-stage research and development (R&D).

Who can apply

Only United States small business concerns (SBCs) that have previously received an NIH SBIR or STTR Phase II award are eligible to submit applications for this opportunity. Only one NIH Phase IIB Strategic Breakthrough award is allowed per project. This NOFO supports Renewal/Resubmission "Type 2" Applications from recipients with NIH Phase II SBIR/STTR awards that are submitted within the first six due dates following the expiration of their budget period. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology

Program contact

National Institutes of HealthSEEDinfo@nih.gov301-402-2541

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