OpenFederal grantOpen to for-profit businessesPA-27-102

NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)

National Institutes of HealthCloses Apr 5, 2027(174 days left)

Does this fit your business?

This is an NIH program for US small businesses that partner with a nonprofit research institution to turn scientific innovation into a commercial product, funding feasibility studies through later-stage R&D. It fits health, biotech, and technology companies doing research and development. Nonprofits, foreign entities, and businesses without a nonprofit research partner should not bother applying.

Best for
US small businesses partnering with a nonprofit research institution, Health and biotech R&D companies, Technology companies commercializing scientific innovations
Not for
Nonprofits and organizations without a small business, Businesses without a nonprofit research partner, Foreign or non-U.S. entities
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
100
Strong Match
Technology & SoftwareMatches your industry (technology, tech, innovation, sttr)
100
Strong Match
Finance & BankingMatches your industry (business)
88
Strong Match
Retail & E-CommerceMatches your industry (small business)
87
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match
Arts & CultureLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Education & TrainingLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Environment & ConservationLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Social Services & NonprofitLimit: This program does not accept nonprofit applicants.
0
Worth Exploring

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research
Who can apply
Small businesses

Questions about this grant

When is the application deadline?
The application deadline is April 5, 2027.
Who can apply for this grant?
Only United States small business concerns, as defined by the Small Business Administration, are eligible to apply. The program requires partnering with a nonprofit research institution, and foreign organizations or non-U.S. components of U.S. organizations are not eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Eligibility is limited to United States small business concerns as defined by the SBA, so check the SBA definition at sbir.gov/apply to confirm your business structure qualifies.
Can a nonprofit apply?
Not as the applicant. Only small businesses can apply, though a nonprofit research institution must be your research partner. Nonprofits in social services, environment, or arts should not apply.

Summary

US small business concerns partnering with a nonprofit research institution can apply for NIH STTR grants funding feasibility studies through later-stage R&D to develop commercial products, including health-related technologies; clinical trials optional.

About this grant

The Small Business Technology Transfer (STTR) grant program helps United States small business concerns (SBCs) that partner with a nonprofit research institution bring scientific innovations to the marketplace. The STTR program supports feasibility studies to later stage research and development (R&D) needed to develop a commercial product.

Who can apply

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity.Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology

Program contact

National Institutes of HealthSEEDinfo@nih.gov301-402-2541

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