ForecastedFederal grantOpen to for-profit businessesPAR-27-040

Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)

National Institutes of HealthCloses Jan 5, 2027(84 days left)

Does this fit your business?

This is an NIH STTR program for US small businesses doing health-related R&D, built around a first-time principal investigator who is moving from research into entrepreneurship. The money funds R&D at the small business plus training, mentoring, and career development for that first-time PD/PI, who must be a US citizen or lawful permanent resident and must never have led an NIH or CDC research grant. If you are a nonprofit, an established researcher who has already been an independent PD/PI, or

Best for
US small businesses with R&D capabilities aligned to NIH's health research mission, First-time principal investigators who are US citizens or lawful permanent residents transitioning from science toentre, Small businesses able to commit a mentor with measurable effort to the project
Not for
Nonprofits and organizations that are not SBA-defined small businesses, Experienced principal investigators who have already led NIH or CDC research grants, Non-US citizens or non-permanent residents seeking to serve as PD/PI
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareMatches your industry (technology, tech, sttr)
100
Strong Match
Healthcare & BiotechMatches your industry (health, clinical)
97
Strong Match
Finance & BankingMatches your industry (business)
85
Strong Match
Retail & E-CommerceMatches your industry (small business)
81
Strong Match
Transportation & LogisticsMatches your industry (transit)
79
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Arts & CultureLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Education & TrainingLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Environment & ConservationLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Social Services & NonprofitLimit: This program does not accept nonprofit applicants.
0
Worth Exploring

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Training, Mentoring, Career development
Who can apply
Small businesses

Questions about this grant

When is the application deadline?
January 5, 2027.
Who can apply for this grant?
Only United States small business concerns (SBCs) as defined by the SBA. The PD/PI must be a first-time investigator who has never been an independent PD/PI on an NIH or CDC research grant (or corresponding non-NIH peer-reviewed research grant) and must be a US citizen or lawful permanent resident. Key personnel must include a mentor with measurable effort committed to the project.
Can a sole proprietor or single-member LLC apply?
The facts only say applicants must be United States small business concerns as defined by the SBA. Whether a sole proprietor or single-member LLC qualifies under that definition is not published here; check SBA's small business criteria.
Can a nonprofit apply?
No. Only US small business concerns are eligible, so nonprofits cannot apply.

Summary

NIH STTR Phase I and Fast-Track grants (R41/R42) for US small business concerns supporting early-career scientists transitioning to entrepreneurship. Funds R&D at the small business plus entrepreneurial training, mentoring, and career development for the first-time PD/PI, who must be a US citizen or lawful permanent resident.

About this grant

The National Institutes of Health (NIH), including the participating Institutes, Centers and Offices, intends to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) Phase I, and Fast-Track grant applications for the Small Business Transition Grant. Through this NOFO, NIH will support early-career scientists transitioning to entrepreneurship. In addition to funding research and development efforts at the SBC, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop responsive projects, including identification of complementary industry mentors and career development resources. This NOFO will utilize the R41/R42 activity code. United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH awarding components identified in this NOFO are encouraged to begin to consider applying for this new NOFO. This opportunity is available to first-time Principal Investigators, and key personnel must include a mentor with measurable effort committed to the project.

Who can apply

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity. Individuals are eligible to serve as the PD/PI if they have never been an independent PD/PI on an NIH or CDC research, or corresponding non-NIH peer-reviewed research grant, and are a U.S. Citizen or Lawful Permanent Resident.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology
  • Entrepreneurship

Program contact

NIH SEED (Small business Education and Entrepreneurial Development) Office of Extramural Research (OER)SEEDinfo@nih.gov301-827-8595

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