ForecastedFederal grantOpen to for-profit businessesPAR-27-039

Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional)

National Institutes of HealthCloses Jan 5, 2027(84 days left)

Does this fit your business?

This is an NIH/CDC SBIR Phase I and Fast-Track program for US small business concerns whose PD/PI is a first-time, early-career scientist moving into entrepreneurship, with required mentoring and entrepreneurial training built in. It is not for established researchers who have already been an independent PD/PI on NIH/CDC or similar peer-reviewed research, and not for nonprofits. Award amounts are not published.

Best for
US small business concerns (SBA-defined) with R&D capabilities matching NIH or CDC research missions, Early-career scientists who have never been an independent PD/PI on an NIH, CDC, or corresponding peer-reviewed research, Small businesses in health, biotech, or technology developing innovative R&D projects, First-time PIs who can commit to entrepreneurial training and pair with a committed industry mentor
Not for
Nonprofits and organizations without small business status, Experienced PIs who have already held an independent NIH or CDC research grant, Businesses without an R&D project relevant to NIH or CDC missions
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareMatches your industry (tech, innovation, sbir)
100
Strong Match
Healthcare & BiotechMatches your industry (health, clinical)
97
Strong Match
Finance & BankingMatches your industry (business)
85
Strong Match
Retail & E-CommerceMatches your industry (small business)
80
Strong Match
Transportation & LogisticsMatches your industry (transit)
79
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Arts & CultureLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Education & TrainingLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Environment & ConservationLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Social Services & NonprofitLimit: This program does not accept nonprofit applicants.
0
Worth Exploring

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Training, Mentoring, Career development
Who can apply
Small businesses

Questions about this grant

When is the application deadline?
January 5, 2027.
Who can apply for this grant?
Only United States small business concerns (SBCs) as defined by the SBA. The PD/PI must be a first-time PI who has never led an independent NIH or CDC research grant (or corresponding non-NIH peer-reviewed research) and must be a U.S. Citizen or Lawful Permanent Resident. Key personnel must include a mentor with measurable effort committed to the project.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Eligibility is limited to United States small business concerns as defined by the SBA, so check the SBA's small business definition at sbir.gov/apply to see whether your entity structure qualifies.
Can a nonprofit apply?
No. Only for-profit United States small business concerns are eligible; nonprofits do not fit this program.

Summary

NIH/CDC SBIR Phase I and Fast-Track grants for US small business concerns to support early-career scientists transitioning into entrepreneurship. Funds R&D at the small business plus entrepreneurial training, mentoring, and career development for the PD/PI. First-time PIs only; key personnel must include a mentor.

About this grant

The National Institutes of Health (NIH) and Centers for Disease Control and Prevention (CDC), including the participating Institutes, Centers and Offices, intend to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) Phase I, and Fast-Track (NIH only) grant applications for the Small Business Transition Grant. Through this NOFO, NIH and CDC will support early-career scientists as they transition into entrepreneurship. In addition to funding research and development efforts at the SBC, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop responsive projects, including identification of complementary industry mentors and career development resources. This NOFO will utilize the R43/R44 activity code. United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH and CDC awarding components identified in this NOFO are encouraged to begin to consider applying for this new NOFO. This opportunity is available to first-time Principal Investigators, and key personnel must include a mentor with measurable effort committed to the project.

Who can apply

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity. Individuals are eligible to serve as the PD/PI if they have never been an independent PD/PI on an NIH or CDC research, or corresponding non-NIH peer-reviewed research grant, and are a U.S. Citizen or Lawful Permanent Resident.

Topics and uses of funds

Topics

  • Health
  • Technology
  • Entrepreneurship
  • Workforce

Program contact

NIH SEED (Small business Education and Entrepreneurial Development) Office of Extramural Research (OER)SEEDinfo@nih.gov301-827-8595

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