ForecastedFederal grantOpen to for-profit businessesPAR-28-017

National Biomedical Research Centers (P50 Clinical Trial Optional)

National Institutes of HealthCloses Jan 25, 2027(104 days left)$7,955,376 – $11,405,967

Does this fit your business?

This is an NIH program funding a small number of large national biomedical research centers (about 2 awards of roughly $8M-$11.4M) that supply advanced equipment, infrastructure, and research models to researchers nationwide, with a focus on human-based methods that reduce, refine, and replace whole-animal use. It is aimed at established research institutions, especially those with existing nonhuman primate colonies. Small businesses, retailers, and any organization without major biomedical R&D,

Best for
Biomedical research centers with existing nonhuman primate colonies, Universities and academic medical centers running NIH-funded basic and translational research, Nonprofits and research institutes developing human-based in vitro and in silico models (NAMs), Large research organizations able to manage multi-million-dollar center awards
Not for
Small businesses and typical for-profit companies without a biomedical research center, Retail, finance, transportation, and other industries with no biomedical research role, Organizations without existing nonhuman primate colonies or major research infrastructure
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (medical, biomedical, clinical)
95
Strong Match
Technology & SoftwareMatches your industry (tech, innovation)
79
Strong Match
Construction & InfrastructureMatches your industry (infrastructure)
58
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
52
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Infrastructure, Equipment, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
$7,955,376 – $11,405,967

Questions about this grant

When is the application deadline?
January 25, 2027.
How much funding can an applicant receive?
Awards range from $7,955,376 to $11,405,967, and NIH expects to make about 2 awards.
Who can apply for this grant?
A wide range of organizations can apply, including state, local, and tribal governments, public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses, other for-profit organizations, independent school districts, public housing authorities, and certain other entities such as federal agencies, U.S. territories, faith-based and community organizations, regional organizations, and foreign institutions. This is an open competition, but it targets research centers with existing nonhuman primate colonies.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full NOFO or contact NIH before assuming you are eligible.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status, nonprofits without 501(c)(3) status (other than institutions of higher education), and private institutions of higher education are all listed as eligible applicants.

Summary

NIH funds National Biomedical Research Centers (~$8-11.4M each, 2 awards) to provide advanced equipment, infrastructure, and research models to researchers nationwide, emphasizing human-based New Approach Methodologies (in vitro/in silico) to reduce, refine, and replace whole-animal use. Open competition; centers with existing nonhuman primate colonies are targeted.

About this grant

The National Biomedical Research Centers (NBRCs) are expected to provide scientific expertise, advanced equipment, infrastructure, and a range of well-characterized research models to researchers across the nation. Research at the NBRCs is supported by almost all NIH Institutes, as well as other federal agencies, including those that safeguard US national security interests. This NOFO emphasizes development of innovative human-based models and new technologies to reduce reliance on live research models. Applications must describe clear, actionable plans to reduce, refine, and replace whole-animal use by developing complementary and alternative approaches tailored to relevant use cases in biomedical research. Scientifically, the NBRCs function as centers of innovation in fundamental science as well as translational hubs that develop, refine, and test novel interventions for ultimate use in human patients. It is NIH’s intention that the NBRCs become leaders in the development and use of human-based approaches, including sophisticated in vitro and in silico models, known as New Approach Methodologies (NAMs). Clinical trials are allowed only as human-based NAMs, where applicable. This notice of funding opportunity (NOFO) is an open competition to increase opportunities for innovation, including NAMs research, at research centers with existing nonhuman primate colonies, and to further leverage existing capabilities in basic and translational research.

Who can apply

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Topics and uses of funds

Topics

  • Science
  • Health
  • Technology

Program contact

Division of Comparative Medicine, Office of Research Infrastructure ProgramsORIPDCM@mail.nih.gov301-451-2074

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