OpenFederal grantOpen to for-profit businessesRFA-DA-25-060

High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

National Institutes of HealthCloses Mar 5, 2027(143 days left)Up to $1,500,000

Does this fit your business?

This is an NIH research grant for studies at the intersection of HIV and substance use, from basic science through clinical and implementation research, aimed at prevention, treatment and cure of HIV among people who use drugs. It is for organizations that can run serious research: you need a detailed research plan, preliminary data, and a clear substance use connection. If you are a small business or nonprofit looking for operating money, service delivery funding, or anything outside HIV andsub

Best for
Universities and academic research teams, Nonprofits with 501(c)(3) status running HIV or substance use research, State, county, city and tribal government research programs, Small businesses and for-profits with a research arm
Not for
Businesses outside healthcare and biotech with no research capability, Foreign organizations or U.S. organizations with foreign components, Applicants looking for service delivery or operating funding rather than research grants
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
78
Strong Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
53
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Colleges and universities, Tribal governments and organizations, Other applicants (see eligibility)
Award range
Up to $1,500,000

Questions about this grant

When is the application deadline?
March 5, 2027.
How much funding can an applicant receive?
The largest award listed is $1,500,000. No cost sharing is required.
Who can apply for this grant?
Universities, nonprofits (with or without 501(c)(3) status), state, county, city and special district governments, federally recognized tribes and tribal organizations, public housing authorities, independent school districts, small businesses, and other for-profit organizations. Foreign entities and foreign components of U.S. organizations are not eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not spell out how sole proprietors or single-member LLCs are treated, so check with NIH before counting on it.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without it may apply, as long as they are not institutions of higher education in those categories.

Summary

NIH funds high-priority research at the intersection of HIV and substance use, from basic science to clinical and implementation studies, aimed at prevention, treatment and cure of HIV among people who use drugs. Open to universities, nonprofits, governments, tribes, small businesses and other for-profits; foreign entities are not eligible.

About this grant

The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use. This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on NIH HIV/AIDS Research Priorities: NOT-OD-20-018: UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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