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OpenFederal grantOpen to for-profit businessesPAR-28-093

Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials (R34 Clinical Trial Optional)

National Institutes of HealthCloses Jul 16, 2029(1000 days left)Up to $450,000

Does this fit your business?

This is an NIH research grant for pilot and feasibility studies that prepare for substance use and HIV prevention, treatment, or services research trials. It is for research organizations, not businesses looking for operating capital; if you are not planning a research trial in these areas, do not apply. The ceiling is $450,000 and the deadline is July 16, 2029.

Best for
Healthcare and biotech research organizations, Universities and research institutions, Nonprofits running substance use or HIV prevention research, Small businesses conducting related research
Not for
Retail, finance, or housing businesses, Companies seeking general operating or growth capital, Organizations with no research component
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, medical, clinical)
88
Strong Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Planning
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $450,000

Questions about this grant

When is the application deadline?
The application deadline is July 16, 2029. The notice was posted on October 19, 2026.
How much funding can an applicant receive?
The largest award is $450,000. No cost sharing is required.
Who can apply for this grant?
Eligible applicants include small businesses, for-profit organizations other than small businesses, nonprofits (with and without 501(c)(3) status), state, county, city, and tribal governments, independent school districts, special district governments, public housing authorities, and public or private institutions of higher education. Foreign organizations may apply, but applications involving foreign subawards or subcontracts will not be considered for funding.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. For-profit organizations other than small businesses and small businesses are both listed as eligible, so check Section III of the NOFO for how your business structure is treated.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH R34 grants fund pilot and feasibility studies to prepare for substance use and HIV prevention, treatment, and services research trials. Eligible applicants include small businesses, for-profits, nonprofits, governments, tribes, and higher education institutions; foreign organizations may apply but foreign subawards are not allowed. Ceiling $450,000.

About this grant

The purpose of this notice of funding opportunity (NOFO) is to support pilot and feasibility studies to inform the design and conduct of efficacy, effectiveness, and/or services research trials. Topics may include: 1) developing interventions to prevent substance use, misuse, or progression to substance use disorder; 2) prevention, treatment, or recovery services research, including research addressing comorbid pain and medical and mental health disorders; and 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthpilotstudies@mail.nih.gov301-402-2541

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