OpenFederal grantOpen to for-profit businessesPAR-28-014

Early-Onset Cancers: Investigating Etiology, Mechanisms, and Early Detection Strategies (RP1 Clinical Trials Optional)

National Institutes of HealthCloses Oct 11, 2029(1092 days left)

Does this fit your business?

This is an NIH/NCI research grant for studying why cancers in adults aged 18-49 are rising, covering causes, biological mechanisms, and early detection. It is for organizations that can run a serious scientific research project over 2 to 5 years, such as universities, cancer research nonprofits, and biotech small businesses. Clinics, service providers, and companies outside biomedical research should not bother applying.

Best for
Research teams at universities or cancer centers studying early-onset cancers, Nonprofits with 501(c)(3) status running biomedical research programs, Small businesses (biotech) with research capabilities in oncology or early detection, Tribal governments or tribal organizations conducting health research
Not for
Businesses outside biomedical research (construction, finance, logistics, etc.), Organizations seeking funding for services, operations, or programs rather than research, Applicants unable to run a 2-5 year scientific study
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
61
Good Match
Environment & ConservationLimit: Closes in 17 days
54
Possible Match
Education & TrainingLimit: Closes in 17 days
50
Possible Match
Energy & Clean TechLimit: Closes in 17 days
49
Possible Match
Arts & CultureLimit: Closes in 17 days
47
Possible Match
Social Services & NonprofitLimit: Closes in 17 days
47
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareLimit: Closes in 17 days
47
Possible Match
Housing & Real EstateLimit: Closes in 17 days
45
Possible Match
Agriculture & FarmingLimit: Closes in 17 days
43
Possible Match
Food & BeverageLimit: Closes in 17 days
43
Possible Match
ManufacturingLimit: Closes in 17 days
41
Possible Match
Retail & E-CommerceLimit: Closes in 17 days
41
Possible Match
Finance & BankingLimit: Closes in 17 days
40
Possible Match
Transportation & LogisticsLimit: Closes in 17 days
40
Possible Match
Construction & InfrastructureLimit: Closes in 17 days
37
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
October 5, 2026.
Who can apply for this grant?
A wide range: private and public universities, state/local/tribal governments, public housing authorities, independent school districts, nonprofits with or without 501(c)(3) status, for-profit organizations, and small businesses. Federal agencies, U.S. territories, regional organizations, and foreign institutions are also listed as eligible in the eligibility text.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full NOFO (PAR-26-150) before assuming.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH/NCI funds research on early-onset cancers (ages 18-49): causes, biological mechanisms, and early detection/risk identification. Eligible applicants include universities, governments, tribes, nonprofits, and small businesses; exploratory (2-year) or full (4-5 year) research projects. Clinical trials optional.

About this grant

This Notice of Funding Opportunity (NOFO) invites applications that investigate the etiology of sporadic non-hereditary early-onset cancers (EOCs: ages 18 to 49 years) and the underlying biological mechanisms that play a role in these cancers to inform prevention and control strategies. The proposed research is expected to advance the understanding of the unexplained rise of cancers in young adults. More specifically, studies should focus on one or more of the following: i) identifying what environmental or lifestyle exposures are driving the increase in the incidence of non-hereditary EOCs, and how these factors vary by patient demographics; ii) examining the biological mechanisms and host responses that underlie the increase in EOCs; and iii) identifying how those at increased risk of developing EOCs can be identified more effectively. In an effort to streamline the application process and sustain momentum in this critical research area, this NOFO supports both exploratory/developmental and standard research projects through a grant award instrument.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Topics and uses of funds

Topics

  • Health
  • Cancer
  • Research
  • Science

Program contact

National Institutes of HealthEarly-OnsetCancersNOFO_DCCPS_DCB_DCP@mail.nih.gov301-402-2541

Related grants

Open opportunities funding similar work, from the same funder or in the same place.

All grantsGrants by stateGrants by industry