OpenFederal grantOpen to for-profit businessesPAR-25-449

Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)

National Institutes of HealthCloses Jun 7, 2028(603 days left)

Does this fit your business?

This is an NIH research grant for rigorous clinical trials studying how mind and body interventions like mindfulness, yoga, acupuncture, and massage affect emotional well-being. It is for experienced research teams with strong preliminary data comparable to an R01 proposal, not for businesses seeking operating funds or organizations new to clinical research. If you cannot run a well-powered mechanistic clinical trial, do not bother applying.

Best for
Research teams with clinical trial experience and preliminary data, Universities and academic medical centers, Nonprofits and healthcare organizations studying mind-body interventions, Small businesses in the health research space
Not for
Businesses without research or clinical trial capability, Organizations without preliminary data to support a trial, Foreign entities or organizations with foreign components
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
80
Strong Match
Energy & Clean TechMatches your industry (efficiency)
69
Good Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
53
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
52
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
49
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
June 7, 2028.
Who can apply for this grant?
Small businesses, for-profit companies, nonprofits (with or without 501(c)(3) status), state and local governments, tribal governments and organizations, public housing authorities, independent school districts, and public or private institutions of higher education may all apply. Foreign organizations and foreign components of U.S. organizations are not eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses are listed as eligible, but the notice does not define whether that includes sole proprietorships, so applicants should confirm with NIH before applying.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and those without it may apply, as long as they are not institutions of higher education (which are separately listed as eligible).

Summary

NIH/NCCIH R61/R33 clinical trial grants for mechanistic research on mind and body interventions (mindfulness, yoga, acupuncture, massage) affecting emotional well-being and whole person health. Open to small businesses, for-profits, nonprofits, universities, governments, and tribal entities; foreign components excluded.

About this grant

The National Center for Complementary and Integrative Health (NCCIH) announces this Notice of Funding Opportunity (NOFO) to solicit applications for research on how mind and body interventions through psychological and/or physical inputs (e.g., mindfulness meditation, yoga, acupuncture, massage, and other brain and/or body based interventions) impact mechanisms of emotional well-being (EWB) and their associations with whole person health (WPH), consistent with the NIH priority to address the health needs of the American people and improve their well-being. The NOFO will support rigorous and well-powered mechanistic research studies that are supported by strong preliminary data. The studies should examine the effects of mind and body interventions on innovative mechanisms of EWB (as the primary outcome), as well as the associated relationship with the Whole Person Health Index (WPHI, as a secondary outcome). To enhance research safety, rigor, and efficiency of NIH-funded mechanistic clinical trials, this initiative will use a two-phased award funding mechanism (R61/R33). The funding will support an initial phase (R61) to establish feasibility benchmarks for the proposed mechanistic clinical trial(s), followed by a second phase (R33) to complete the full-scale trials, which will be contingent upon successful completion of R61 milestones. Applications should provide preliminary data that are comparable in quality and quantity to those expected for an R01 proposal.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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