OpenFederal grantOpen to for-profit businessesPAR-25-447

NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)

National Institutes of HealthCloses May 8, 2028(573 days left)

Does this fit your business?

This is not a money grant. It is an NIH/X01 mechanism that lets approved applicants run analyses on NHLBI TOPMed genetic and multi-omics data for heart, lung, blood, and sleep disorders and deposit results in public NIH databases — and the NOFO states no funding will be provided. It fits research teams with the computational and genomics capacity to do that work; any business or organization expecting a check to cover costs should not bother applying.

Best for
Genomics and multi-omics researchers with access to TOPMed data, Universities and academic medical centers doing heart, lung, blood, or sleep research, Nonprofits and research institutes able to deposit data in NIH public databases, Small businesses with bioinformatics or functional genomics capability
Not for
Businesses looking for actual funding — this NOFO provides none, Companies outside genomics, biotech, or health data research, Organizations unable or unwilling to deposit results in public NIH databases
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
76
Strong Match
Technology & SoftwareCurrently accepting applications
61
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
49
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
May 8, 2028.
Who can apply for this grant?
Small businesses, other for-profits, nonprofits (with or without 501(c)(3) status), public and private universities, independent school districts, state, county, city, and special district governments, public and Indian housing authorities, and federally recognized and other Native American tribal governments and organizations. Foreign organizations, federal agencies, and certain serving institutions such as HBCUs and Hispanic-serving institutions are also listed as eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Sole proprietors are not named in the eligible applicant codes, and single-member LLCs would fall under the small business or for-profit categories only if they qualify as such; check with NIH or the full NOFO before assuming eligibility.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status, other than institutions of higher education, are both listed as eligible applicants.

Summary

NHLBI invites applications to use TOPMed program data to generate integrated genetic and multi-omics datasets on heart, lung, blood, and sleep disorders, with results deposited in public NIH databases. Eligible applicants include small businesses, other for-profits, nonprofits, universities, and state, local, and tribal governments. No funding is provided under this NOFO.

About this grant

This Notice of Funding Opportunity (NOFO) invites applications to use NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate a large volume of integrated genetic and multi-omics data to facilitate discovery of the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders. No funding will be provided under this NOFO. The genomic data and related phenotypic data will be deposited in a public NIH-designated controlled-access database such as the database for Genotypes and Phenotypes (dbGaP) and NHLBIs BioData Catalyst (BDC). The overall goal is to move from simply cataloguing genetic associations to understanding how genetic factors contribute to HLBS diseases at the molecular and cellular levels. This transformation will help move TOPMed from genetic Map to Mechanism with potential applications of AI and ML tool sets where possible, enabling functional genomics research that will accelerate mechanistic personalized medicine

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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