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OpenFederal SBIR/STTROpen to for-profit businessesARPA-H 05

ARPA-H Lineage Topic

Department of Health and Human Services, ARPA-HCloses Sep 30, 2027(345 days left)

Does this fit your business?

This is an SBIR/STTR topic for US for-profit small businesses with 500 or fewer employees that want to finish developing, find secondary applications for, or commercialize technology that originated from ARPA-H funded efforts. If your business has no connection to ARPA-H funded technology, or you are a nonprofit, do not bother applying. Award amounts are not published, so check the official solicitation before planning around the money.

Best for
For-profit US small businesses with 500 or fewer employees working on ARPA-H originated health technology, Technology and software startups commercializing ARPA-H funded R&D, Healthcare and biotech small businesses advancing ARPA-H funded products, Small businesses partnering with a US nonprofit research institution under STTR
Not for
Nonprofits and organizations without ARPA-H funded technology to commercialize, Businesses with more than 500 employees including affiliates, Businesses not majority owned and controlled by US citizens or permanent residents
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareMatches your industry (technology, tech, sbir, sttr)
93
Strong Match
Healthcare & BiotechMatches your industry (health)
76
Strong Match
Finance & BankingMatches your industry (business)
67
Good Match
Retail & E-CommerceMatches your industry (small business)
66
Good Match
Agriculture & FarmingLimit: Primarily for minority-owned businesses
54
Possible Match
Construction & InfrastructureLimit: Primarily for minority-owned businesses
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Primarily for minority-owned businesses
54
Possible Match
Food & BeverageLimit: Primarily for minority-owned businesses
54
Possible Match
Housing & Real EstateLimit: Primarily for minority-owned businesses
54
Possible Match
ManufacturingLimit: Primarily for minority-owned businesses
54
Possible Match
Transportation & LogisticsLimit: Primarily for minority-owned businesses
54
Possible Match
Arts & CultureLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Education & TrainingLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Environment & ConservationLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Social Services & NonprofitLimit: This program does not accept nonprofit applicants.
0
Worth Exploring

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research, Commercialization
Who can apply
Small businesses

Questions about this grant

When is the application deadline?
Proposals are accepted starting June 11, 2026, and the topic closes September 30, 2027. Check the official solicitation for the exact due time.
Who can apply for this grant?
For-profit US small businesses with 500 or fewer employees, including affiliates, that are more than 50% owned and controlled by US citizens or permanent residents. The business must be registered in SAM.gov before submitting. Under SBIR the principal investigator must be primarily employed by the business; under STTR the business partners with a US nonprofit research institution or university that does at least 30% of the work.
Can a sole proprietor or single-member LLC apply?
The facts state applicants must be for-profit US small businesses with 500 or fewer employees, but they do not specifically address sole proprietors or single-member LLCs. Check the official solicitation.
Can a nonprofit apply?
No. This topic is for for-profit small businesses only.

Summary

SBIR/STTR topic for US for-profit small businesses (≤500 employees) to advance, commercialize, and translate technologies originating from ARPA-H funded efforts. Funds Phase I and Phase II R&D to finish developing products, explore secondary applications, and reach commercial self-sufficiency.

About this grant

he purpose of this topic supports the advancement, commercialization, and translation of technologies that originated from ARPA-H funded efforts. It is intended to help small businesses and startups develop viable products based on these technologies. ARPA-H’s goal is to give small businesses an off-ramp to finish developing their technology/product, explore secondary or interim applications of the technology, and time to achieve self-sufficiency.

Program: SBIR/STTR, Phase I and Phase II Agency: Department of Health and Human Services, ARPA-H Topic number: ARPA-H 05 Solicitation: 7599226SN106 Proposals accepted from June 11, 2026 Closes September 30, 2027. Check the official solicitation for the exact due time. Official solicitation: https://sam.gov/workspace/contract/opp/34fa75da1d484987bd6dbc882deab889/view Listed on SBIR.gov: https://www.sbir.gov/topics/12790. SBIR.gov copies agency solicitations and can lag behind them; the official solicitation is the final word.

Who can apply

Small businesses only: a for-profit US business with 500 or fewer employees, including affiliates.

More than 50% owned and controlled by US citizens or permanent residents (some agencies also accept majority ownership by venture capital, hedge fund or private equity firms; the solicitation says).

SBIR: the principal investigator is primarily employed by the business. STTR: the business partners with a US nonprofit research institution or university, which does at least 30% of the work.

Registered in SAM.gov before submitting.

Check the official solicitation for its own conditions, proposal limits and security review.

Topics and uses of funds

Topics

  • Health
  • Technology
  • Science

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