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OpenFederal SBIR/STTROpen to for-profit businessesARPA-H 04

Breaking Ground: The First Curative, Durable, Non-Surgical Therapy for Endometriosis

Department of Health and Human Services, ARPA-HCloses Sep 30, 2027(345 days left)

Does this fit your business?

This is an ARPA-H SBIR/STTR topic for US for-profit small businesses (500 or fewer employees, majority US-owned) doing R&D on a novel, non-surgical, curative therapy for endometriosis. If you are not a small business developing biomedical therapies, do not bother. Nonprofits cannot apply; STTR applicants must partner with a US nonprofit research institution.

Best for
US for-profit small businesses with 500 or fewer employees, Biotech or health R&D companies developing non-surgical endometriosis therapies, STTR applicants partnering with a US nonprofit research institution or university
Not for
Nonprofits and organizations of any other type, Businesses not doing health or biomedical R&D, Companies without SAM.gov registration or majority US ownership
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareMatches your industry (sbir, sttr)
80
Strong Match
Healthcare & BiotechMatches your industry (health)
74
Good Match
Energy & Clean TechLimit: Primarily for minority-owned businesses
54
Possible Match
Housing & Real EstateLimit: Primarily for minority-owned businesses
54
Possible Match
Retail & E-CommerceLimit: Primarily for minority-owned businesses
54
Possible Match
ManufacturingLimit: Primarily for minority-owned businesses
53
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Food & BeverageLimit: Primarily for minority-owned businesses
52
Possible Match
Construction & InfrastructureLimit: Primarily for minority-owned businesses
51
Possible Match
Finance & BankingLimit: Primarily for minority-owned businesses
51
Possible Match
Agriculture & FarmingLimit: Primarily for minority-owned businesses
50
Possible Match
Transportation & LogisticsLimit: Primarily for minority-owned businesses
48
Possible Match
Arts & CultureLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Education & TrainingLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Environment & ConservationLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Social Services & NonprofitLimit: This program does not accept nonprofit applicants.
0
Worth Exploring

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research
Who can apply
Small businesses

Questions about this grant

When is the application deadline?
September 30, 2027. Proposals are accepted starting June 11, 2026, and you should check the official solicitation for the exact due time.
Who can apply for this grant?
For-profit US small businesses with 500 or fewer employees, including affiliates, that are more than 50% owned and controlled by US citizens or permanent residents. SBIR applicants need the principal investigator primarily employed by the business; STTR applicants must partner with a US nonprofit research institution that does at least 30% of the work. Registration in SAM.gov is required before submitting.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. The stated rule is a for-profit US business with 500 or fewer employees, majority owned and controlled by US citizens or permanent residents, so check the official solicitation for how your structure is treated.
Can a nonprofit apply?
No. Only small businesses may apply. Under the STTR track, a nonprofit research institution can be a partner that performs at least 30% of the work, but it cannot be the applicant.

Summary

SBIR/STTR funding for US small businesses (≤500 employees, majority US-owned) to develop novel, non-surgical, curative therapies for endometriosis—reducing or deactivating endometrial implants, decreasing inflammation, and preventing lesion growth or regrowth. Phase I and Phase II awards; STTR requires partnership with a US nonprofit research institution.

About this grant

The purpose of this topic aims to develop treatments for endometriosis that are non-surgical. Proposers are expected to develop novel, non-surgical therapies to decrease the size or deactivate endometrial implants, to decrease inflammation cause by implants, and / or prevent growth or regrowth of the lesions. Broadly, this should be a novel, non-surgical, curative treatment for endometriosis.

Program: SBIR/STTR, Phase I and Phase II Agency: Department of Health and Human Services, ARPA-H Topic number: ARPA-H 04 Solicitation: 7599226SN106 Proposals accepted from June 11, 2026 Closes September 30, 2027. Check the official solicitation for the exact due time. Official solicitation: https://sam.gov/workspace/contract/opp/34fa75da1d484987bd6dbc882deab889/view Listed on SBIR.gov: https://www.sbir.gov/topics/12789. SBIR.gov copies agency solicitations and can lag behind them; the official solicitation is the final word.

Who can apply

Small businesses only: a for-profit US business with 500 or fewer employees, including affiliates.

More than 50% owned and controlled by US citizens or permanent residents (some agencies also accept majority ownership by venture capital, hedge fund or private equity firms; the solicitation says).

SBIR: the principal investigator is primarily employed by the business. STTR: the business partners with a US nonprofit research institution or university, which does at least 30% of the work.

Registered in SAM.gov before submitting.

Check the official solicitation for its own conditions, proposal limits and security review.

Topics and uses of funds

Topics

  • Health
  • Science

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