OpenFederal grantOpen to for-profit businessesRFA-OD-25-010

Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

National Institutes of HealthCloses Sep 28, 2028(716 days left)

Does this fit your business?

This is an NIH research infrastructure grant for teams building or improving research models of human disease — including biology-based new approach methodologies — that serve the interests of multiple NIH institutes, not one narrow disease area. It fits biotech research organizations, universities, and research-active small businesses; it does not fit retail, finance, housing, or any business without a genuine research and development operation, and foreign entities are barred entirely.

Best for
Biotech and life-science research teams building disease models or NAMs, Small businesses doing health-related R&D, Universities and research nonprofits, State, county, city, or tribal government research programs
Not for
Retail, finance, or real estate businesses with no research operation, Projects serving a single disease or a single NIH institute's interests, Foreign organizations or U.S. projects with foreign components
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
93
Strong Match
Education & TrainingMatches your industry (stem)
74
Good Match
Social Services & NonprofitMatches your industry (community)
74
Good Match
Construction & InfrastructureMatches your industry (infrastructure)
66
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
September 28, 2028.
How much funding can an applicant receive?
The total program funding is $5,000,000 with about 6 awards expected, but the maximum award per applicant is not published in the notice. NIH R24 awards are typically resource grants, but no per-award amount is stated here.
Who can apply for this grant?
Small businesses, other for-profit organizations, nonprofits (with or without 501(c)(3) status), private and public higher education institutions, state, county, and city governments, and federally recognized Native American tribal governments. Foreign organizations, foreign components of U.S. organizations, and foreign collaborations are not eligible.
Can a sole proprietor or single-member LLC apply?
The notice does not specifically address sole proprietors or single-member LLCs. Small businesses are listed as eligible, but you should confirm your business structure qualifies under the NIH Grants Policy Statement before applying.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH/ORIP R24 resource grants to develop, characterize, or improve research models of human health and disease, including biology-based new approach methodologies, and improve access to model-derived data. Open to small businesses, other for-profits, nonprofits, state/county/city governments, federally recognized tribes, and higher education institutions; foreign entities ineligible.

About this grant

The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems in order to align with the ORIP"s NIH-wide mission and programs. Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs. Applications to develop models that relate strictly to a specific disease or a select area of research or that do not have a broad impact on the NIH-wide research community will not be accepted. Projects that predominantly address the research interests of one NIH IC but are only peripherally related to the research interests of other ICs will also not be accepted, if submitted in response to this notice of funding opportunity (NOFO).

Who can apply

Refer to Section III. Eligibility Information of the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Topics and uses of funds

Topics

  • Science
  • Health
  • Research

Program contact

National Institutes of HealthORIPDCM@mail.nih.gov301-402-2541

Related grants

Open opportunities funding similar work, from the same funder or in the same place.

All grantsGrants by stateGrants by industry