OpenFederal grantOpen to for-profit businessesPAR-25-383

Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)

National Institutes of HealthCloses Jan 28, 2028(472 days left)

Does this fit your business?

This NIH program funds therapeutic and diagnostic devices for nervous or neuromuscular system disorders, covering prototype development, safety testing, regulatory approvals, and clinical feasibility studies. It is for teams with a device already in development, not early ideas or unrelated products. Retail, housing, food, or any business outside medical devices should not bother applying.

Best for
Small businesses developing a medical device for a nervous-system or neuromuscular disorder, Universities and academic investigators running translational device work, Nonprofits and device manufacturers with established collaborations, Teams needing regulatory, reimbursement, or commercialization help from NIH-funded consultants
Not for
Businesses with no medical device or nervous-system focus, Companies seeking general working capital or unrelated product development, Retail, housing, or food-sector businesses with no device angle
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (medical, clinical)
91
Strong Match
Education & TrainingMatches your industry (stem)
74
Good Match
Technology & SoftwareMatches your industry (tech)
73
Good Match
ManufacturingMatches your industry (manufacturing)
68
Good Match
Finance & BankingMatches your industry (business)
65
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Clinical trials, Device development, Regulatory approval, Commercialization, Testing
Who can apply
Small businesses, For-profit companies, Nonprofits, Colleges and universities, State and local governments, Tribal governments and organizations, Individuals, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
January 28, 2028.
Who can apply for this grant?
Individuals, institutions, and businesses developing their own devices can apply, including small businesses, for-profit companies, universities, nonprofits, tribal organizations, and state, local, and federal government entities. Foreign organizations are also eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Individuals are listed as eligible applicant types, but you should confirm your business structure qualifies with NIH before applying.
Can a nonprofit apply?
Yes. Nonprofits with and without 501(c)(3) status are listed as eligible applicants.

Summary

NIH cooperative agreement program funding translational activities and clinical feasibility studies for therapeutic and diagnostic devices targeting nervous or neuromuscular system disorders. Open to individuals, institutions, and businesses developing their own devices, including small businesses, universities, nonprofits, and governments. Supports prototype implementation, safety testing, IDE/IR

About this grant

The purpose of this announcement is to encourage investigators to pursue translational activities and clinical feasibility studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, as well as a subsequent clinical feasibility study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress. Participants in Blueprint MedTech receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants to receive assistance with specialty areas including regulatory, reimbursement, intellectual property, commercialization, and strategic partnerships. Participants can also augment their project with NIH contract research organizations that specialize in large animal testing, sterilization testing, biocompatibility assessment, manufacturing, and medical monitoring. Individuals, institutions, or businesses developing their own devices or that already have established collaborations with device manufacturers are welcome to apply directly to this NOFO or any of the companion opportunities. For more information see BP MedTech website.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Medical devices
  • Neuroscience
  • Research
  • Technology

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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