OpenFederal grantOpen to for-profit businessesPAR-26-040

Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)

National Institutes of HealthCloses Mar 5, 2029(874 days left)Up to $250,000

Does this fit your business?

This is an NIH research grant for teams doing serious bioinformatics, computational biology, or biomedical data science work using AI, machine learning, or large-scale computing. If your business is not built around extracting knowledge from complex biological or biomedical data, do not apply. Retail, finance, and housing businesses have no angle here.

Best for
Biotech and biomedical research teams, Software and AI developers working on biomedical data, Universities and research institutions, Nonprofits with computational biology programs
Not for
Retail, finance, or real estate businesses with no biomedical research angle, Organizations relying on foreign subawards or subcontracts, Applicants seeking funding for anything other than research or R&D
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, medical, biomedical, clinical)
96
Strong Match
Technology & SoftwareMatches your industry (tech, innovation)
86
Strong Match
Education & TrainingMatches your industry (learning)
73
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $250,000

Questions about this grant

When is the application deadline?
March 5, 2029.
How much funding can an applicant receive?
The largest single award is $250,000, with total program funding of $2,500,000 and about 10 awards expected.
Who can apply for this grant?
Small businesses, for-profit companies, nonprofits (with or without 501(c)(3) status), universities, state/local/tribal governments, public housing authorities, independent school districts, and other organizations may apply. Foreign organizations are eligible, but applications involving foreign subawards or subcontracts will not be considered for funding.
Can a sole proprietor or single-member LLC apply?
The facts do not say. The eligible applicant codes list small businesses and for-profit organizations generally, but the NOFO's Section III would need to be checked for how sole proprietors are treated.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible.

Summary

NIH/NLM R01 research grants for bioinformatics, translational bioinformatics, and computational biology projects using AI, machine learning, and large-scale computing to extract knowledge from complex biomedical data. Eligible applicants include small businesses, for-profits, nonprofits, universities, state/local/tribal governments, and other organizations; foreign entities may apply but foreign

About this grant

The National Library of Medicine (NLM) seeks applications for research projects that drive groundbreaking innovation and advanced development in the fields of bioinformatics, translational bioinformatics, and computational biology. The primary goal of this initiative is to support the creation and implementation of cutting-edge methods, tools, and approaches that can transform the landscape of biomedical data science. This NOFO aims to address the growing need to leverage transformative technologies — such as artificial intelligence (AI), machine learning, and large-scale computational platforms — to extract actionable knowledge from vast, diverse, and complex biological datasets. By enabling more effective interpretation and integration of multi-dimensional biological and biomedical data, this research will ultimately contribute to improving individual and population health outcomes.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology

Program contact

National Institutes of HealthNLMProgram@nih.gov301-402-2541

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