OpenFederal grantOpen to for-profit businessesPAR-26-042

Research Grants in Clinical Informatics (R01 Clinical Trial Optional)

National Institutes of HealthCloses Mar 5, 2029(874 days left)Up to $250,000

Does this fit your business?

This is an NIH research grant for clinical informatics: building and testing tools and methods that turn health data like EHRs, clinical notes, imaging, and patient-generated data into usable knowledge. It suits small businesses, for-profits, nonprofits, governments, and universities doing genuine health-data R&D, not companies selling existing products or services. Retail, finance, and housing organizations with no health-data research angle should not bother.

Best for
Small businesses building clinical informatics or health-data tools, For-profit companies doing health data R&D, Nonprofits and universities running clinical informatics research, State, local, and tribal governments with health data research programs
Not for
Retail, finance, or housing businesses with no health-data research angle, Companies wanting a grant to run operations or deliver services, Applicants planning to route money through foreign subawards or subcontracts
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
93
Strong Match
Technology & SoftwareMatches your industry (digital)
81
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $250,000

Questions about this grant

When is the application deadline?
March 5, 2029. The notice was posted February 10, 2026, so there is a long runway before applications are due.
How much funding can an applicant receive?
Awards range from $0 to $250,000, with about 10 awards expected out of $2,500,000 in total program funding. No cost sharing is required.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), state and local governments, tribal governments and tribal organizations, public housing authorities, independent school districts, and public or private institutions of higher education. Foreign organizations may also apply, but applications involving foreign subawards or subcontracts will not be considered for funding.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check Section III of the NOFO before assuming you can apply.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are eligible, as long as they are not institutions of higher education.

Summary

NIH/NLM R01 grants for innovative clinical informatics research—developing, implementing, and evaluating tools and methods to turn health data (EHRs, clinical notes, imaging, patient-generated data) into actionable knowledge. Eligible: states, local/tribal governments, nonprofits, for-profits including small businesses, and higher education institutions.

About this grant

The National Library of Medicine (NLM) seeks applications for innovative research in clinical informatics. The overarching goal of this forthcoming program is to catalyze the development and advancement of novel informatics methodologies that empower clinicians, patients, and the broader public to better understand, manage, and improve health and health care delivery. This NOFO will support research focused on the design, implementation, and evaluation of clinical informatics tools and methods that enable data-driven discovery, promote evidence-based decision-making, and support personalized and precision health care. Emphasis will be placed on domain-independent, scalable, and reusable/reproducible approaches for the discovery, analysis, organization, and management of health-related digital objects—including electronic health records (EHRs), clinical notes, imaging data, and patient-generated data. The aim is to transform raw and heterogeneous health data into actionable knowledge, to develop innovative tools, and to implement practical applications that can be generalized across multiple clinical settings and populations. Projects should demonstrate the potential to accelerate scientific insights, improve clinical workflows, and ultimately lead to improved health outcomes.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Topics and uses of funds

Topics

  • Health
  • Technology
  • Science

Program contact

National Institutes of HealthNLMProgram@nih.gov301-402-2541

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