OpenFederal grantOpen to for-profit businessesPAR-25-184

Early Stage Testing of Pharmacologic or Neuromodulatory Device-based Interventions for the Treatment of Mental Disorders (R61/R33 Clinical Trial Required)

National Institutes of HealthCloses Oct 15, 2027(367 days left)

Does this fit your business?

This is an NIH/NIMH clinical trial grant (R61/R33) for early-stage testing of drugs or neuromodulatory devices that treat mental disorders, and it requires an experimental therapeutics design that tests the intervention's mechanism of action. It fits clinical research teams — universities, nonprofits, small businesses, and for-profits running early-phase trials. If you are not running clinical research on mental health interventions, do not bother.

Best for
Small businesses and for-profits developing pharmacologic or neuromodulatory device-based interventions for mental, Universities and academic medical centers running clinical trials, Nonprofits (501(c)(3) and others) doing mental health clinical research, Tribal governments and organizations
Not for
Businesses outside clinical research (construction, retail, transportation, general software), Organizations without clinical trial capability or a mechanism-of-action research design
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
76
Strong Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
53
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
53
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
53
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
49
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
October 15, 2027.
Who can apply for this grant?
Universities, nonprofits (with and without 501(c)(3) status), small businesses, other for-profits, state/local/county governments, special district governments, independent school districts, public housing authorities, and federally recognized tribal governments and tribal organizations. Foreign (non-U.S.) entities are also eligible, along with certain serving institutions such as HBCUs, Hispanic-serving institutions, and Alaska Native and Native Hawaiian Serving Institutions.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full NOFO (PAR-25-184) on Grants.gov before assuming you can apply.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without it (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH/NIMH R61/R33 clinical trial grant supporting early-stage testing of pharmacologic or neuromodulatory device-based interventions for mental disorders, using experimental therapeutics designs that test mechanism of action. Eligible applicants include universities, nonprofits, small businesses, for-profits, state/local/tribal governments, and foreign entities.

About this grant

NIMH requires an experimental therapeutics approach for the development and testing of therapeutic interventions, in which studies both evaluate the clinical effect of an intervention and generate information about the mechanisms underlying a disorder or an intervention response. As part of NIMHs Clinical Trial Pipeline, this NOFO encourages early stage testing of pharmacologic interventions with novel mechanisms of actions or device-based interventions. More specifically, this NOFO is intended to support early stage testing of pharmacologic or device-based interventions using a protocol design where the presumed mechanism of action of the intervention is adequately tested, to provide meaningful information where target modulation yields a dose-dependent neurophysiological/clinical/behavioral effect.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Mental health
  • Science
  • Clinical research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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