OpenFederal grantOpen to for-profit businessesRFA-HL-26-016

Catalyze: Enabling Technologies and Transformative Platforms for HLBS Research (R33 - Clinical Trials Not Allowed)

National Institutes of HealthCloses Dec 23, 2027(436 days left)Up to $350,000

Does this fit your business?

This is an NIH research grant for validating platform technologies that move heart, lung, blood, and sleep (HLBS) discoveries toward human testing, with a $350,000 ceiling and clinical trials explicitly not allowed. It fits small biotech, medtech, and research organizations with a genuine HLBS connection. Retail, finance, housing, and other businesses with no health research angle should not bother applying.

Best for
Small biotech or medtech companies with a platform technology aimed at heart, lung, blood, or sleep diseases, Universities and academic health centers translating basic discoveries toward human testing, Nonprofits and research institutes working on HLBS diagnostics or therapeutics, Translational research teams preparing technologies for clinical validation without running trials
Not for
Businesses outside healthcare, biotech, or medical technology with no HLBS connection, Organizations wanting funding for clinical trials (this program explicitly does not allow them), Retail, finance, housing, or other industries with no research or health angle
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
84
Strong Match
Technology & SoftwareMatches your industry (tech)
80
Strong Match
Transportation & LogisticsMatches your industry (transit)
69
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $350,000

Questions about this grant

When is the application deadline?
December 23, 2027.
How much funding can an applicant receive?
The largest award is $350,000. No cost sharing is required.
Who can apply for this grant?
Small businesses, for-profit companies, nonprofits (with or without 501(c)(3) status), public and private institutions of higher education, state, local, county, and tribal governments, public housing authorities, and certain other organizations such as HBCUs, Hispanic-serving institutions, and Alaska Native or Native Hawaiian serving institutions. Foreign organizations are not eligible, though foreign components of U.S. organizations are allowed.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full solicitation before counting on it.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH NHLBI Catalyze program (R33, clinical trials not allowed) funds validation of transformative multi-use platforms/technologies that advance translation of basic discoveries toward human testing for heart, lung, blood, and sleep (HLBS) diseases. Eligible applicants include small businesses, for-profits, universities, nonprofits, and state/local/tribal governments; ceiling $350,000.

About this grant

The goal of the NHLBI Catalyze Program is to provide a comprehensive suite of support and services to facilitate the transition of basic science discoveries into viable diagnostic and therapeutic candidates that have been cleared for human testing, and to develop translational researchers fluent in product development and entrepreneurship. This specific Catalyze Enabling Technologies and Transformative Platforms initiative will support needed to rigorously validate transformative, multi-use platforms or technologies that can enable. Well-suited applications must offer the potential to significantly accelerate and/or transform the areas of early detection and screening, model development, clinical diagnosis, treatment, control, behavior, prevention or epidemiology. Proposed platforms and technologies may have widespread applicability but must be able to improve the outlook for HLBS-related diseases and disorders.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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