OpenFederal grantOpen to for-profit businessesPAR-25-287

Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)

National Institutes of HealthCloses Jan 7, 2028(451 days left)

Does this fit your business?

This is an NIH R01 grant for developing next-generation brain stimulation devices for mental health treatment—either entirely novel devices or major hardware/software upgrades to FDA-approved ones. It is for serious R&D teams with device engineering capability; incremental changes like routine software updates are explicitly out of scope, and clinical trials are not allowed. Companies outside healthcare device development, such as construction, retail, or finance, should not bother applying.

Best for
Small businesses and for-profit companies developing brain stimulation hardware or software, Universities and research institutions running device R&D, Nonprofits working on mental health technology, Tribal entities and governments with device development programs
Not for
Companies making incremental software updates to existing devices, Organizations planning clinical trials, Businesses outside device development, such as construction, retail, or finance
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
89
Strong Match
Technology & SoftwareMatches your industry (tech, software)
84
Strong Match
Food & BeverageMatches your industry (food)
68
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
53
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research
Who can apply
State and local governments, Colleges and universities, Nonprofits, Small businesses, For-profit companies, Tribal governments and organizations, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The deadline is January 7, 2028.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), public and private institutions of higher education, state and local governments, school districts, public housing authorities, and federally recognized tribal governments can all apply. The eligibility text also lists foreign organizations, HBCUs, Hispanic-serving institutions, and other specific entity types.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses and for-profit organizations are listed as eligible, but the notice does not break down business structures.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH R01 grants to develop next-generation brain stimulation (neuromodulation/neurostimulation) devices for treating mental health disorders—either novel devices or major hardware/software enhancements to FDA-approved devices. Eligible applicants include small businesses, for-profit organizations, universities, nonprofits, governments, and tribal entities; clinical trials not allowed.

About this grant

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications seeking to develop the next generation of brain stimulation devices for treating mental health disorders. Applications are sought that will either 1) develop novel brain stimulation devices or 2) significantly enhance, by means of hardware/software improvements, the effectiveness of brain stimulation devices that are currently U.S. Food and Drug Administration (FDA)-approved or cleared. Novel devices should move beyond existing electrical/magnetic stimulation and develop new stimulation techniques capable of increased spatiotemporal precision as well as multi-focal, closed-loop approaches. Applications seeking to develop new capabilities should focus on significant enhancement of the spatial resolution, depth of delivery, and/or precision of the device. Incremental changes to existing devices (e.g., software updates) are not withinthe scope of this announcement.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Technology
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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