OpenFederal grantOpen to for-profit businessesRFA-HL-26-002

NHLBI Outstanding Investigator Award (OIA) (R35 Clinical Trial Optional)

National Institutes of HealthCloses Apr 28, 2027(197 days left)

Does this fit your business?

This is a National Institutes of Health award for experienced researchers, not a typical small-business grant. It funds established investigators who already lead at least two NHLBI R01-equivalent awards, giving them up to seven years of flexible support for heart, lung, blood, and sleep research. If your organization does not have a principal investigator with that track record, do not bother applying.

Best for
Experienced NHLBI-funded investigators leading at least two R01-equivalent awards, Universities and research institutions running heart, lung, blood, or sleep research programs, Nonprofits and government entities with established HLBS research programs, Small businesses and for-profit organizations with NHLBI-funded principal investigators
Not for
Small businesses without an NHLBI-funded principal investigator, Organizations with no existing heart, lung, blood, or sleep research program, First-time grant applicants or early-career researchers
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
77
Strong Match
Environment & ConservationMatches your industry (environment)
75
Strong Match
Technology & SoftwareMatches your industry (innovation)
72
Good Match
Energy & Clean TechMatches your industry (energy)
69
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureMatches your industry (creative)
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Nonprofits, Colleges and universities, State and local governments, Small businesses, For-profit companies, Tribal governments and organizations, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is April 28, 2027.
Who can apply for this grant?
Eligible applicants include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, state and local governments, federally recognized and other Native American tribal governments and organizations, independent school districts, public housing authorities, small businesses, and for-profit organizations other than small businesses. The award is aimed at experienced Program Directors/Principal Investigators who currently lead at least two NHLBI R01-equivalent awards.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses are listed among eligible applicant types, but the award targets experienced investigators already holding at least two NHLBI R01-equivalent awards, so a sole proprietor without that research track record would not fit.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NHLBI Outstanding Investigator Award provides up to seven years of flexible support to experienced investigators already leading at least two NHLBI R01-equivalent awards, to sustain ambitious heart, lung, blood, and sleep research programs. Eligible applicants include universities, nonprofits, governments, tribes, and for-profit organizations, including small businesses.

About this grant

The purpose of the NHLBI Outstanding Investigator Award (OIA) is to promote scientific productivity and innovation by providing long-term support and increased flexibility to experienced Program Directors/Principal Investigators (PDs/PIs) who are currently PDs/PIs on at least two NHLBI R01-equivalent awards and whose outstanding record of research demonstrates their ability to make major contributions to heart, lung, blood and sleep (HLBS) research. The OIA is intended to support a research program, rather than a research project, by providing the primary and most likely sole source of NHLBI funding on individual grant awards. The OIA will support the research program of NHLBI-funded investigators for up to seven years. The OIA will provide investigators increased freedom to conduct research that breaks new ground or extends previous discoveries in new directions. It will also allow PDs/PIs to take greater risks and to pursue research that requires a longer timeframe. Research supported by the OIA must be within the scope of the NHLBI mission (https://www.nhlbi.nih.gov/about/mission-statement). It is anticipated that the OIA will: Provide a stable funding environment, thereby improving productivity and facilitating nimble, ambitious, creative research; Accelerate scientific innovation by enabling flexibility in pursuing new research directions as they arise, since PDs/PIs will not be bound to specific aims proposed in advance of the studies; Reduce the time researchers spend writing grant applications and managing multiple grant awards, thereby allowing more time to be devoted to conducting research; Facilitate commitment of PDs/PIs to research through increased stability of funding; and Enable PDs/PIs to devote more time and energy to mentoring students and junior scientists and providing scientific service.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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