Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

Does this fit your business?

This is an NIH research grant for organizations developing medications, devices, or behavioral interventions to prevent or treat substance use disorders and overdose, from preclinical work through clinical trials. It fits healthcare and biotech researchers with a credible path toward regulatory approval or clinical adoption; it does not fit businesses outside that research pipeline, including retail, software, finance, or housing organizations with no clinical development component. Awards canbe

Best for

Healthcare and biotech organizations developing SUD or overdose interventions, Universities and research institutions running preclinical or clinical studies, Nonprofits and tribal organizations working on substance use disorder research, Small businesses and for-profits with a research pipeline toward regulatory approval

Not for

Businesses with no research or clinical development component, Organizations outside healthcare and biotech seeking general operating or expansion funding

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for

Research, R&D, Clinical trials

Who can apply

Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Award range

Up to $3,000,000

Questions about this grant

When is the application deadline?

The application deadline is August 21, 2028.

How much funding can an applicant receive?

The largest award listed is $3,000,000. No other award amounts are published.

Who can apply for this grant?

Eligible applicants include universities, nonprofits with or without 501(c)(3) status, state, county, city and township governments, special district governments, independent school districts, public housing authorities, federally recognized and other Native American tribal organizations, small businesses, and other for-profit organizations. Federal agencies, faith-based and community organizations, regional organizations, U.S. territories, and foreign entities are also eligible.

Can a sole proprietor or single-member LLC apply?

The facts do not say. Small businesses are eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full NOFO before assuming you can apply.

Can a nonprofit apply?

Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status, other than institutions of higher education, are both listed as eligible applicants.

Summary

NIH grants supporting research to discover and develop interventions—medications, devices, behavioral approaches—to prevent or treat substance use disorders and overdose, from preclinical through clinical stages. Eligible applicants include universities, nonprofits, state/local/tribal governments, small businesses, and other for-profit organizations; foreign entities and federal agencies may also.

About this grant

Who can apply

Topics and uses of funds

Program contact