OpenFederal grantOpen to for-profit businessesPAR-28-022

Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2027, 2028, and 2029 (P50 Clinical Trial Required)

National Institutes of HealthCloses Sep 25, 2029(1076 days left)

Does this fit your business?

This is an NIH National Cancer Institute program funding large translational cancer research centers (P50 SPOREs), with a clinical trial required and a goal of reaching a translational human endpoint within the grant period. It is for established research institutions with the capacity to run human cancer research and clinical trials, not for small businesses or organizations without a research operation. Total program funding is $25,000,000 across about 12 expected awards; no per-award amount,,

Best for
Cancer research centers at universities and hospitals, Research teams running translational cancer projects with clinical trials, Institutions with existing human biology and clinical research infrastructure
Not for
Small businesses without cancer research or clinical trial capability, Organizations seeking general health services or treatment funding, Applicants unable to commit to translational research with human endpoints
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
72
Good Match
Education & TrainingMatches your industry (stem)
61
Good Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
53
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
53
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
53
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
52
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
51
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
50
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
47
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials, Translational research, R&D
Who can apply
State and local governments, Colleges and universities, Nonprofits, For-profit companies, Small businesses, Tribal governments and organizations, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
January 25, 2027.
How much funding can an applicant receive?
The notice lists total program funding of $25,000,000 with about 12 awards expected, but it does not state a per-award amount.
Who can apply for this grant?
State, county, city, and special district governments, public and private institutions of higher education, independent school districts, public housing authorities, federally recognized and other Native American tribal governments and organizations, nonprofits with or without 501(c)(3) status, for-profit organizations other than small businesses, and small businesses may apply. Eligibility text also lists federal agencies, U.S. territories, faith-based and community organizations, regional organizations, and foreign institutions.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible.

Summary

NIH/NCI P50 SPORE center grants funding investigator-initiated translational cancer research aimed at improved prevention, early detection, diagnosis, and treatment of organ-specific or related cancers, with clinical trials required. Open to governments, universities, nonprofits, tribal organizations, and for-profit organizations including small businesses.

About this grant

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPOREs). Based on the proposed research, applications may be jointly funded with the National Institute of Dental and Craniofacial Research (NIDCR). This is a re-issuance of PAR-23-284 . The program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer or a highly related group of cancers. The research supported through this program must be translational and be based on human biology research using cellular, molecular, structural, biochemical, and/or genetic experimental approaches. SPORE projects must reach a translational human endpoint within the project period of the grant.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Topics and uses of funds

Topics

  • Health
  • Science
  • Cancer research
  • Translational research
  • Clinical trials

Program contact

National Institutes of HealthNCI_SPORE_Program@nih.gov301-402-2541

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