OpenFederal grantOpen to for-profit businessesPAR-25-290

Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)

National Institutes of HealthCloses Jan 7, 2028(451 days left)

Does this fit your business?

This is an NIH research grant (R01) for invasive neural recording and stimulation studies in humans aimed at understanding the brain circuitry behind mental health disorders. It funds research only, not development of new technologies or therapies, so it fits established research teams, not companies building products. Small businesses can apply on paper, but only ones that actually run or partner on clinical neuroscience research should bother.

Best for
Research teams at universities and medical centers, Nonprofits running human neuroscience studies, Small businesses with clinical research capability, Tribal and government entities with research programs
Not for
Companies developing devices, software, or therapies, Businesses with no research or clinical capability, Organizations seeking funding for services or operations
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
78
Strong Match
Technology & SoftwareMatches your industry (tech)
66
Good Match
Energy & Clean TechMatches your industry (wind)
64
Good Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
52
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
52
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
51
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
50
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
January 7, 2028. The opportunity was posted on November 21, 2024.
Who can apply for this grant?
State, county, city, and special district governments; public and private institutions of higher education; independent school districts; public housing authorities; federally recognized tribal governments and other tribal organizations; nonprofits with and without 501(c)(3) status; small businesses; and other for-profit organizations. The eligibility text also lists foreign organizations, HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, faith-based and community-based organizations, and federal agencies among others.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not define what counts as a small business or address sole proprietors specifically, so check the full NOFO (PAR-25-290) before assuming you qualify.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible.

Summary

NIH R01 grant supporting invasive neural recording and stimulation studies in humans to advance understanding of neural circuitry underlying mental health disorders. Open to universities, nonprofits, governments, tribes, and small or other for-profit businesses; funds research, not technology or therapy development.

About this grant

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to target a gap in the scientific knowledge of neural circuit function related to mental health disorders. Researchers should target specific questions suited to invasive recording modalities that have high translational potential. Development of new technologies and therapies are outside the scope of this NOFO.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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