OpenFederal grantOpen to for-profit businessesPA-25-305

NIH Research Project Grant (Parent R01 Clinical Trial Required)

National Institutes of HealthCloses Jan 7, 2028(451 days left)

Does this fit your business?

This is NIH's parent R01 grant for a discrete research project that must include at least one clinical trial, and it fits organizations with real clinical research capability aligned to an NIH institute's mission. Small businesses and for-profits can apply, but only if they are running health research. Retail, finance, housing, education, and general tech businesses should not bother; nothing in the notice points to them.

Best for
Healthcare and biotech organizations running clinical trials, Universities and research institutions, Nonprofits with research capacity, Tribal organizations and governments with health research programs
Not for
Businesses outside healthcare and biotech with no clinical research capability, Organizations unable to run a clinical trial, Applicants without a project aligned to an NIH institute's mission
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
84
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is January 7, 2028.
Who can apply for this grant?
Eligible applicants include small businesses, for-profit organizations, nonprofits (with and without 501(c)(3) status), state, county, city and township governments, special district governments, independent school districts, public housing authorities, Federally recognized and other Native American tribal governments and organizations, and public and private institutions of higher education. Other eligible entities include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, HBCUs, Tribally Controlled Colleges and Universities, faith-based and community-based organizations, regional organizations, U.S. territories or possessions, foreign organizations, and,
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH parent R01 for clinical trials; open to small businesses, for-profits, nonprofits, governments, tribes, universities, and other eligible entities; funds a discrete research project aligned with participating NIH institute missions.

About this grant

The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Notice of Funding Opportunity Announcement requires that at lease 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Clinical research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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