OpenFederal grantOpen to for-profit businessesPAR-25-374

Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed)

National Institutes of HealthCloses May 7, 2028(572 days left)Up to $1,000,000

Does this fit your business?

This is an NIH research grant (R01) for preclinical testing of repurposed drugs and drug combinations for Alzheimer's disease and related dementias, using mouse models only; clinical trials are not allowed. It fits labs and research organizations with drug-testing capability, not companies looking for general business funding. If you cannot run rigorous preclinical mouse-model studies, do not bother applying.

Best for
Biotech and pharma R&D teams with mouse-model preclinical capability, Universities and academic research labs, Nonprofits and research institutes focused on Alzheimer's and dementia, Small businesses doing preclinical drug testing
Not for
Businesses with no research or lab capability, Organizations seeking funding for clinical trials, Industries outside health and biotech, such as construction, transportation, or manufacturing
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
74
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
53
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
53
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
49
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
State and local governments, Colleges and universities, Nonprofits, For-profit companies, Small businesses, Tribal governments and organizations, Other applicants (see eligibility)
Award range
Up to $1,000,000

Questions about this grant

When is the application deadline?
May 7, 2028.
How much funding can an applicant receive?
The largest single award is $1,000,000, and total program funding is also listed as $1,000,000. No cost sharing is required.
Who can apply for this grant?
Small businesses, for-profit companies, universities, nonprofits with or without 501(c)(3) status, state/local/tribal governments, public housing authorities, independent school districts, and certain other entities such as foreign organizations and faith-based or community-based organizations. Clinical trials are not allowed.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not publish a rule on sole proprietors or single-member LLCs specifically.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible.

Summary

NIH R01 grant funding preclinical testing in mouse models of drugs and drug combinations for Alzheimer's disease and related dementias, including repurposing and combination with non-pharmacologic interventions. Eligible applicants include small businesses, for-profits, universities, nonprofits, governments, and tribal organizations; clinical trials not allowed.

About this grant

This Notice of Funding Opportunity (NOFO) invites applications that propose to use mouse models to conduct rigorous preclinical testing of drugs or drug combinations currently used for other conditions, as well as investigational drugs at various stages of clinical development, predicted to be efficacious in AD/ADRD. This initiative will also support preclinical testing of repurposable or investigational drug candidates in combination with non-pharmacologic interventions leading to robust translational outcomes. The central goal is to establish robust proof of concept that will enable rational drug repurposing and combination therapy development for the treatment and prevention of AD/ADRD.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

Related grants

Open opportunities funding similar work, from the same funder or in the same place.

All grantsGrants by stateGrants by industry