OpenFederal grantOpen to for-profit businessesPAR-25-032

NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)

National Institutes of HealthCloses Jan 7, 2027(86 days left)

Does this fit your business?

This is an NIH/NHLBI R34 pilot grant for research studies that inform the design or planning of a future Phase II-IV clinical trial in heart, lung, blood, or sleep disorders. It fits organizations with clinical research capacity, including small businesses, universities, and nonprofits; it does not fit businesses outside health research, such as retail, finance, or housing, and foreign entities cannot apply as primary applicants.

Best for
Research teams planning a Phase II-IV clinical trial in heart, lung, blood, or sleep disorders, Universities and academic medical centers, Nonprofits and hospitals with clinical research capacity, Small businesses and for-profits developing interventions in NHLBI's mission area
Not for
Businesses with no clinical research capability or no connection to heart, lung, blood, or sleep disorders, Retail, finance, housing, and other industries the notice does not mention, Foreign organizations as primary applicants
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
80
Strong Match
Education & TrainingMatches your industry (training)
72
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
January 7, 2027.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), private and public institutions of higher education, state, county, city, and special district governments, tribal governments and tribal organizations, independent school districts, public housing authorities, and certain other institutions such as HBCUs, Hispanic-serving institutions, and faith-based or community-based organizations. Foreign entities may not apply as primary applicants, though foreign components of U.S. organizations are allowed.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full NOFO (PAR-25-032) before assuming you are eligible.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH/NHLBI R34 pilot grants to plan Phase II-IV clinical trials for heart, lung, blood, and sleep disorders. Open to small businesses, for-profits, universities, nonprofits, state/local/tribal governments, and other organizations; foreign entities may not apply as primary applicants.

About this grant

This Notice of Funding Opportunity Announcement (NOFO) intends to supports studies that are both necessary and sufficient to inform the planning of a Phase II-IV clinical trial within NHLBI's mission. The NHLBI expects that applications to this NOFO will describe the planned clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent trial. Furthermore, this NOFO will support research projects that are designed to provide results that will be sufficient to inform the future trial without further studies. The planned Phase II, III, or IV trial must be primarily intended to test the efficacy, safety, clinical management, or implementation of intervention(s) in the prevention and/or treatment of heart, lung, blood, and sleep disorders. In contrast to the study start up or preparation phase of NHLBI funding opportunities for clinical trials (as described at https://www.nhlbi.nih.gov/grants-and-training/funding-opportunities-and-contacts/clinical-trials-optimization), the R34 mechanism is intended to provide new information that answers a scientific or operational question(s) which may be pragmatic in nature and, therefore, informs the final development of a Phase II-IV clinical trial. Regardless of the results of the R34, support of the proposed future clinical trial will require a new application.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

Related grants

Open opportunities funding similar work, from the same funder or in the same place.

All grantsGrants by stateGrants by industry