OpenFederal grantOpen to for-profit businessesPAR-25-353

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional)

National Institutes of HealthCloses Oct 25, 2027(377 days left)

Does this fit your business?

This is an NIH research program for multidisciplinary teams discovering and developing new drugs, ligands, and neurostimulation devices to treat mental disorders, substance use disorders, and alcohol use disorder. It is for serious R&D organizations, especially academia-industry partnerships, not for businesses looking for general operating money or a quick grant. If your company is not doing preclinical drug or device research in this space, do not bother.

Best for
Biotech and pharma R&D teams working on mental health, SUD, or AUD treatments, Universities and academic medical centers running multidisciplinary drug or device discovery programs, Small businesses developing neurostimulation or circuit-engagement devices, Nonprofits and research institutes partnering with industry on preclinical development
Not for
Retail, finance, housing, or education businesses with no drug or device R&D, Companies seeking funding for a single investigator's narrow project (the companion U01 FOA fits that better), Organizations outside the U.S. or with non-U.S. components
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
82
Strong Match
Technology & SoftwareCurrently accepting applications
68
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
October 25, 2027.
Who can apply for this grant?
Universities (public and private), small businesses and other for-profit companies, nonprofits with or without 501(c)(3) status, state, county, city, and special district governments, tribal governments and tribal organizations, public housing authorities, independent school districts, and certain federal agencies. Foreign organizations and non-U.S. components of U.S. organizations are not eligible, though foreign components as defined by NIH policy are allowed.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check with NIH before assuming you can apply.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without it (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH cooperative agreement program funding multidisciplinary research groups to discover and develop new drugs, ligands, and neurostimulation/circuit-engagement devices for treating mental disorders, substance use disorders, and alcohol use disorder. Eligible applicants include universities, small and other for-profit businesses, nonprofits, state/local/tribal governments, and federal agencies; U.S

About this grant

Reissue of PAR-20-119. This FOA encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This FOA supports a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach. Projects seeking support for a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies should consider the companion U01 FOA.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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