OpenFederal grantOpen to for-profit businessesPAR-25-321

Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional)

National Institutes of HealthCloses Jan 7, 2028(451 days left)

Does this fit your business?

This is an NIH/NCI exploratory research grant (R21) for bioengineering projects that demonstrate the feasibility of new tools or improvements in biomedical, pre-clinical, or clinical research and care delivery. It fits small businesses, for-profits, universities, nonprofits, governments, and tribal entities doing health-related engineering R&D. If your business is not developing or studying biomedical technology, there is nothing in this notice for you.

Best for
Small businesses and for-profits developing biomedical or bioengineering technology, Universities and research institutions, Nonprofits working on health research, Tribal and government entities doing bioengineering R&D
Not for
Retail, finance, housing, and other businesses with no biomedical or engineering research angle, Organizations looking for general operating or commercialization funding rather than exploratory R&D
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (medical, biomedical, clinical)
93
Strong Match
Technology & SoftwareCurrently accepting applications
74
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
January 7, 2028.
Who can apply for this grant?
Small businesses, other for-profit organizations, nonprofits (with or without 501(c)(3) status), state, local, and tribal governments, public and private institutions of higher education, public housing authorities, and certain other entities such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, HBCUs, and faith-based or community-based organizations. Foreign (non-U.S.) entities are also listed as eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full NOFO (PAR-25-321) before assuming you are eligible.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without it may apply, as long as they are not institutions of higher education (those are covered under a separate eligible category).

Summary

NIH/NCI R21 grants for exploratory bioengineering research demonstrating feasibility of new capabilities or improvements in biomedical, pre-clinical, or clinical research and care delivery. Eligible applicants include small businesses, other for-profits, universities, nonprofits, governments, and tribal entities.

About this grant

Through this engineering-oriented Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to encourage submissions of exploratory/developmental Bioengineering Research Grant (EBRG) applications to demonstrate feasibility and potential utility of new capabilities or improvements in quality, speed, efficacy, operability, costs, and/or accessibility of solutions to problems in basic biomedical, pre-clinical, or clinical research, clinical care delivery, or accessibility.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Technology

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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