Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 - Clinical Trial Optional)

Does this fit your business?

This is an NIH exploratory research grant (R21) for developing new newborn screening tests or therapies for fatal, disabling, or high-priority genetic conditions. It fits healthcare and biotech researchers, including small businesses, universities, and nonprofits; it is not for companies outside medical research, and the $200,000 cap and exploratory scope will not fund late-stage development or anything unrelated to newborn screening science.

Best for

Small biotech or medtech companies developing newborn screening tests or treatments, Universities and academic medical centers doing exploratory research on screenable genetic disorders, Nonprofits and research institutes focused on rare genetic conditions, Tribal, state, or local government entities with research programs in newborn screening

Not for

Retail, construction, finance, and other businesses with no connection to medical research, Organizations seeking funding for operations, equipment, or services rather than research, Applicants needing more than $200,000

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for

Research

Who can apply

Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Award range

Up to $200,000

Questions about this grant

When is the application deadline?

November 16, 2027.

How much funding can an applicant receive?

The largest single award is $200,000, and total program funding is listed at $200,000. This is an exploratory R21 grant, so awards are small.

Who can apply for this grant?

Small businesses, for-profit companies, nonprofits (with or without 501(c)(3) status), public and private universities, state, county, city, and special district governments, federally recognized tribal governments, tribal organizations, public housing authorities, and independent school districts. Foreign organizations, faith-based and community organizations, and certain minority-serving institutions are also eligible.

Can a sole proprietor or single-member LLC apply?

The facts do not say. Small businesses are eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full solicitation or contact NIH before assuming you are eligible.

Can a nonprofit apply?

Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH R21 grants for exploratory research on novel newborn screening approaches and therapies for screenable or high-priority genetic disorders. Open to small businesses, for-profits, nonprofits, universities, and state/local/tribal governments; no cost sharing required.

About this grant

Who can apply

Topics and uses of funds

Program contact